Mouth Dissolving Tablets Essay

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Mouth dissolving tablets are a new and exciting alternative to traditional tablet and iquid medication dosages. Mouth dissolving tablets dissolve on the tongue, with the aid of saliva. Mouth dissolving tablets can dissolve in as little as 1 to 2 seconds or as long as 2 to 3 minutes, depending on the different fast dissolve/disintegration technologies used to manufacture them. Orally disintegrating tablets are an appealing dosage form for many reasons. Health professionals find the mouth disintegrating tablets as a good alternative for traditional tablets and liquid forms. Pediatric, geriatric, bedridden, and developmentally disabled patients are especially well suited for this alternative to traditional tablets. Medications used for treating…show more content…
It was observed that all the tablets pass the test for weight variation and content uniformity. Hardness of all tablets was between 2.5 to 3.5 kg/cm3, while the friability below 1%, all they have good mechanical strength. Water absorption ratio, & disintegration time of all batches were observed within 22 sec and 180 seconds respectively. It was found that as the concentration of sodium starch glycolate, and croscarmellose decreases, the disintegration time also decreases ,but when the concentration of sodium starch glycolate increase the disintegration time also increases, which may be because of gel formation. Tablets containing combination of sodium starch glycolate, croscarmellose & crospovidone showed 100% drug release within 10 minutes. It was observed that with the increase in concentration of superdisintegrants, the disintegration time decreased in following order: - Crospovidone > crosscarmellose > sodium starch glycolate.Faster dissolution was obtained when combination of superdisintegrants was used. Dissolution studies indicated, that tablets prepared by combination of three superdisintegrants showed rapid

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