Multiple System Atrophy (MSA)
Multiple System Atrophy (MSA)
Multiple System Atrophy (MSA) most commonly known as multiple organ failure is a very progressive disorder in which affects the autonomic nervous system. Multiple System Atrophy mostly affects the autonomic nervous system which is the system in which the non-voluntary processes in the body is monitored by, such as blood pressure, digestion, and pulse. During the progressive part of MSA, the disease results in extreme loss of function and death of several nerve cells in the brain and spine. To this day there is no diagnosed known cause to Multiple System Atrophy. MSA is so rare, in fact it only affects 15,000-50,000 people total in a lifetime. This disorder is most common in males
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Symptoms of autonomic failure that are mostly commonly seen in the early stages of Multiple System Atrophy include, fainting spells, heart rate issues, erectile dysfunction, motor impairments, muscle tremor or loss of muscle coordination, difficulties with speech and walking, as well as bladder control. Most early symptoms of MSA are very common to those of Parkinson 's disease. Clients with MSA usually suffer from orthostatic hypotension as well. Orthostatic hypotension is when a client makes a sudden movement, such as going from sitting to standing, their blood pressure remains uncontrollable and drops suddenly, causing light headedness, or fainting (Multiple System Atrophy Fact Sheet, 2014, par. …show more content…
The two different types include MSA-P and MSA-C. MSA-P is the Parkinsonian form of MSA which has the similar symptoms to Parkinson 's disease such as moving slow, muscle tremor, and stiffness. MSA-C is the cerebellar version of Multiple System Atrophy. The cerebellar part of the brain is involved with coordination. MSA-C has symptoms including ataxia, difficulty with speech and swallowing, and abnormal eye movements.
In males, the most common first symptom of MSA is erectile dysfunction. Usually males ignore this symptoms as a huge problem because of the age that MSA is most commonly onset. Since 50 years old and later is the most common age that males develop MSA, they usually see the erectile dysfunction as a normal part of getting older. MSA is associated with deterioration and shrinking of portions of your brain which are the ones that regulate internal body functions, digestion and motor skills. The difficulty swallowing, eating, digestion, and muscle coordination is caused rapidly by this
It is also proposed that using IL-2 levels for diagnosis has greater specificity and sensitivity compared to those using oligoclonal immunoglobulins or FLCIg. ( Oehninger-Gatti C,) There are reports claiming that an increase in the concentration of some oxidative stress markers can be detected in body fluids of patients with MS. At last, some studies published Within the last decade, suggest a relation between viral infections and MS, (Nahid Akhyani, )many of them suggesting Epstein-Barr virus (EBV) as a potential etiologic factor in MS (8), but still no specific viral agent has been definitively found to cause
The disease Duchenne muscular Dystrophy (DMD) is the most common form of muscular dystrophy (1) in fact 3 out of every 10,000 births will result in a male born with this disorder (2). DMD is a recessive sex linked disorder that can only be passed down to the child if his mother is the carrier (2, 3). Symptoms for DMD are confinement to a wheel chair by the age of 11at the latest and are expected to die in their twenties to forties (2, 4). This is because DMD causes progressive muscle weakness and will reduce muscle tone throughout the body. Muscle weakness will usually begin its onset by the age of three (4).
3, 4, 6b, 8, 10 Clinical signs include muscle weakness and atrophy, exercise intolerance and a paddling gait. Dysphagia and regurgitation are frequently seen with degeneration of the esophageal and pharyngeal muscles. Creatine kinase levels are elevated and there are bizarre discharges on EMG.
Tay-Sachs is a rare, inherited, metabolic disease that is caused by a defective gene on chromosome 15. This defect causes the body to not make a protein called hexosaminidase which leads to chemicals building up. These chemicals destroy the nerve cells in the brain and the spinal cord. Tay-Sachs is also called GM2 gangliosidosis, HexA deficiency, Hexosaminidase A deficiency, and Hexosaminidase alpha-subunit deficiency. Tay-Sachs is most common in infants and children.
Higgins was diagnosed with Multiple Sclerosis when she was in college around twenty two years old. She was suffering from loss of vision and horrible migraines. She had a vision test, an MRI, and then a spinal tap. The MRI showed four lesions on her brain and the spinal tap confirmed the diagnosis because her spinal serum tests differently than healthy humans. Every month Higgins has an injection of medicine that is meant to help slow down the progression of her MS.
Around 75% of individuals develop limb-onset ALS, with initial involvement occurs in the upper and lower extremities. The other 25% develop bulbar-onset ALS, with initial involvement occurring in the bulbar muscles. The bulbar muscles are considered to be the muscles of the mouth and throat that are responsible for speech and swallowing. Bulbar-onset ALS is more common in middle-aged women with the prevalent beginning stage symptoms being difficulty swallowing, chewing and
Duchenne Muscular Dystrophy Introduction Duchenne Muscular Dystrophy is a dangerous and rare disorder. It is transferred through family generations because it is a genetic disease. Duchenne Muscular Dystrophy is referred to by many names including DMD, Duchenne Syndrome, and Pseudohypertrophy. DMD is when the body cannot make dystrophin so it results in muscle weakness.
She yelled for help because it was hard for her to breathe. She noticed that the left side of her arm was weak and useless, which is sign of motor deterioration. Parkinson's disease is a type of condition that starts off very slowly, and later on, it progressively takes control of all body movements. Some early signs of Parkinson’s disease are depression, emotional changes, major headaches, and trouble sleeping at night, and inexplicable aches and pains (Levy, 30).
Robin Williams and the Lewy Body Struggle On July 21, 1952 a boy named Robin Williams was born who would someday go on to be an Hollywood star. He would go on to entertain the world for decades with his hilarious comedy. To the regular person he seemed perfectly happy and healthy, but he was neither.
Introduction Multiple Sclerosis is a neurological disorder that affects the central nervous system, causing damage to the nerve cells, which could cause permanent damage, leaving those who suffering from the disease with a myriad of lifelong issues. According to Mayo Clinic (2018), “Signs and symptoms of MS vary widely and depend on the amount of nerve damage and which nerves are affected.” The damage varies from patient to patient; with many of the symptoms include numbness and tingling of the extremities, mental health issues, such as depression, vision issues, speech impairment, balance issues, and chronic fatigue, as well as incontinence and bowel issues. In more advanced stages, cognitive function can change, such as memory impairment,
The word “lateral” refers to the area where the nerve cells are in the spinal cord. As this area is affected by ALS it creates scarring or hardening which is that last part of the name “sclerosis” (What Is ALS?). The symptoms of ALS include the muscles to not operate correctly in the legs, arms, face, and tongue. Eventually, a person with ALS can lose the ability to breathe too, but recent technologies have made a tubing system to allow you to breathe. ALS is all physically affected, not logical thought.
MS, as discussed, can be slow or fast progressing. Also, there are other neurological diseases that are symptomatically similar to MS as they also show signs of demyelination. MS is often diagnosed using both clinical and MRI results. The physician would usually first take a family history as genetics also play a role (albeit small) in MS presentation. The physician would move on to complete a physical examination, often looking signs such as lack of balance and coordination, loss of vision, and decreased emotional and language functions.
According to WebMD, the first type of spinal muscular disease is the most serious variant due to the fact that most children with type 1 fail to live past two years of age from breathing issues because the muscles that control breathing are feeble. Symptoms of type 1 include limp arms and legs as well as the trouble swallowing. Moreover, type 2 spinal muscular atrophy occurs with children from six to eighteen months old. According to the National Organization for Rare Diseases, children with type 2 are able to sit on their own, but fail to walk more than 10 feet, however, once they mature to a teenager, they will be unable to sit independently. A symptom common for people diagnosed with type 2 is the fingers quivering (National Organization for Rare Diseases).
1.1 INTRODUCTION Myasthenia Gravis as well as known by the name (MG) is autoimmune neuromuscular disease that caused weakness in the skeletal muscles, the muscle that are used for movement to do activity of daily living. Myasthenia Gravis are caused by the neuromuscular disorder. The neuromuscular disorder for Myasthenia Gravis occurs when communication between nerve cells and muscles becomes impaired. This neuromuscular disorder caused the important muscle to make the contraction movement from occurring, that caused muscle weakness, resulting rapid fatigue of any of the muscles under voluntary control. Symptoms include drooping of one or both eyelids, diplopia and difficulty swallowing, chewing and speaking.
Although in MS, the spinal cord signs are asymmetrical involving only a part of the long ascending and descending tracts, i.e., paraplegia and complete sensory loss are not usual. Clinical sings include: a rapidly evolving symmetrical or asymmetrical paraparesis or paraplegia occurring over several hours or days, ascending paresthesia, loss of deep sensibility in the feet, sphincter disturbance, and bilateral Babinski sign. An infectious illness is reported from some patients preceding the onset of the symptoms. In this case a postinfectious demyelinating disease is more likely to happen rather than