Neevirapine Matrix Tablets Case Study

746 Words3 Pages
6.2 Formulation development of Nevirapine matrix tablets. The formulation development of Nevirapine matrix tablets was started with using different viscosity grades of HPMC such as HPMC K4M, HPMC K15M, HPMC K100M and METALOSE 90 SH. MCC was used as diluent, water was used as the solvent to prepare the wet mass, talc and aerosil were used as anti adherent and glidant, magnesium stearate was used as lubricant. 6.2.1 Formulation development with HPMC K4M The formulation development was initiated with the use of HPMC K4M. The tablets were prepared at different polymer concentrations such as 10% , 20% and 30% of the polymer to the target tablet weight. The tablets were prepared by wet granulation method. Formulations were prepared by mixing nevirapine and HPMC K4M uniformly. MCC was added to the drug and polymer mixture and blended thoroughly for 5 min. water was added to the drug, polymer, and MCC mixture and mixes it thoroughly to form a wet mass. It was sieved through sieve no.18 to form granules.Then the granules were collected and dried in an hot air oven at 60◦C for 20 min.The dried granules were passed through sieve no.30. Then the dried granules were pre lubricated with Aerosil and talc and finally lubricated with magnesium stearate. The tablets were compressed using 17.5X7.5 mm oval shaped punch.Good physicochem- ical properties were observed for of the prepared matrix tablets. The weight variation was observed within the range (650 mg). Friability of the prepared

More about Neevirapine Matrix Tablets Case Study

Open Document