Ocular Lymphoma Case Study

Abstract: Ocular lymphomas are rare malignancies that display a myriad of clinical manifestations; therefore the diagnosis can be a challenging task. Almost all intraocular lymphomas are B cell non-Hodgkin’s lymphomas. Although the orbit is an extranodal site where lymphocytes are not found under normal conditions, lymphoid tumors are the third most common cause of proptosis in the adults. Ocular lymphomas are most challenging cases seen by ophthalmologists and are more serious eye conditions, leading possibly to blindness and death. We describe a series of 4 cases which presented as ocular adnexal masses and a view on clinicopathological details.

Key-words: B cell NHL,

Introduction Majority of the orbital lymphomas are B cell non-Hodgkin's lymphomas and tend to present in the 6th and 7thdecades. Presentation before the age of 20 is rare. In children, orbital leukemic infiltrates are much more common than lymphoma. Most subtypes of lymphoma have a female-to-male risk of 1.5:1. Lymphomas of the eye are usually located superiorly and

Complete hemogram was done which was normal except for the reactive forms of lymphocytes were seen. Systemic evaluation was done to examine for any primaries or metastasis USG of neck, abdomen and pelvis was normal. Serum LDH was mildly elevated. MRI head was done which was suggestive of either an inflammatory pseudotumor or a neoplasia of lacrimal gland. Excision biopsy of the lesion done under GA was sent for Histopathological evaluation.

Histopathology: On gross shows a single container of a pale white to pale brown irregular tissue bits measuring 0.7 x 0.4 cm. Microscopic examination showed lacrimal gland with dense lymphocytic infiltrate within the lobules and interlobular stroma.A few thin walled congested blood vessels are seen in the lacrimal gland lobules. The features were suggestive of Non Hodgkins lymphoma of diffuse small cell