ipl-logo

Omalizumab Research Paper

668 Words3 Pages

Omalizumab
Omalizumab is a humanized monoclonal antibody used for the treatment of persistent allergic asthma. In general, allergic reactions are triggered by IgE present in human immune system. Allergies predominately occur on skin surface, in gut, in respiratory tract, or any other sites of parasitic invasion. The persistent allergic asthma is the allergic reaction at the respiratory tract that initiates inflammation, bronchoconstriction and mucus secretion. Omalizumab binds to the Cε3 domain of IgE and forms hexamer complex that inhibits the immune response by preventing IgE from attaching to mast cells and other effector cells, thus down-regulating the FcεRI receptors (see Appendix for more information).

Genentech, Inc., a U.S. subsidiary …show more content…

As a result, FDA has added information about these potential risks to the drug label. The review also found that there is no difference in the rates of cancer between those patients being treated with Xolair and those who were not being treated with Xolair. However, due to limitations of 5-year study in analyzing the cancer rates associated with Xolair, FDA is currently not in the state of ruling out the potential risk of cancer with this drug. So this information was also added to the Warnings and Precautions section of the drug label. These current events are said to be the major drawbacks in Xolair manufacturing …show more content…

(2003). Asthma, Rhinitis, Other Respiratory Diseases: Brief Communication: Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma. The Journal of Allergy And Clinical Immunology, 11(1), 87-90. doi:10.1067/mai.2003.49
D'Amato, G., Stanziola, A., Sanduzzi, A., Liccardi, G., Salzillo, A., Vitale, C., & ... D'Amato, M. (2014). Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review. Multidisciplinary Respiratory Medicine, 9(1), 23. doi:10.1186/2049-6958-9-23
Omalizumab- Mechanism of action [Online Image]. Aspergillus & Aspergillosis Website. Retrieved from http://www.aspergillus.org.uk/content/omalizumab-new-treatment-option-allergic-bronchopulmonary-aspergillosis-abpa
Ruffin, C. G., & Busch, B. E. (2004). Omalizumab:A recombinant humanized anti-IgE antibody for allergic asthma. American Journal of Health-System Pharmacy, 61(14), 1449-1459.Retrived from http://www.medscape.com/viewarticle/483809_2
Xolair - Biological Therapy (2015). Drugdevelopment-Technology. Retreived from http://www.drugdevelopment-technology.com/projects/xolair/

Show More
Related

  • Resistance Varies In Mike's Conducting Air

    656 Words  | 3 Pages

    How does this improve Mike’s asthma? - Albuterol is used to relax the muscles that are in the bronchioles to relieve breathing. It relaxes smooth muscle by decreasing the calcium ions. Calcium ions are necessary to produce muscle contraction. It improves Mike’s asthma because it is relaxing his smooth muscle, which allows for a clear pathway for airflow to help him breath

    Read More

  • Myiesha Leonard Case Study

    334 Words  | 2 Pages

    year- old that loves to follow behind his brother. She reported that he is busy and loves playing with others. Ms. Leonard reported that Samuel currently has asthma and takes two medications. Samuel currently takes Albuterol and Bromfed DM. She reported no asthma attacks.

    Read More

  • Miracle Bamboo Pillow Research Paper

    470 Words  | 2 Pages

    All these allergens can lead to allergic reactions such as itching, sneezing, wheezing and watery eyes. However, in order to minimize allergies and reduce your exposure to dust mites, it's recommended to change your old mattress and buy a hypoallergenic product which has been tested for allergies. These days, the memory foam and latex mattresses without coils and springs are the best options. One of the best items available on the market, which can help reduce symptoms like stuffy nose, itchy eyes and sneezing, it is the Essentia mattress. As such, if you are looking for a healthier product which can provide a good night's sleep you can confidently choose Essentia

    Read More

  • Emily Vonder Meulen's Suicide

    365 Words  | 2 Pages

    This article begins with the tragic accounts of a 13-year-old teenage girl who assumed she was having an asthma attack at school and took a few puffs of her inhaler for her asthma, however sadly she went into anaphylactic shock from a food allergy and later died. Statistically, millions of Americans have asthma and many of them also have food allergies, which puts them at a greater risk of experiencing severe allergic reactions. Emily Vonder Meulen, another 13-year-old who died due to a food allergy, was always extremely careful about her food selection’s and aware of her anaphylactic symptoms. Her death was caused by a sandwich she ate at a restaurant that had trace elements of peanuts, which Emily had a severe allergy to peanuts. However,

    Read More

  • PPACA Response Paper

    592 Words  | 3 Pages

    In March 2010 President Obama signed into law the Patient Protection and Affordable Care Act (PPACA). The goal was to make health care more affordable, accessible and improve quality, for seniors, families and businesses. One component of the PPACA is the Hospital Readmission Reduction Program (HRRP). The objective of HRRP is to reduce hospital readmissions for selected disease categories where Centers for Medicare and Medicaid Services (CMS) data shows there is considerable room for improvement. This program creates financial incentives for hospitals to reduce cost, implement quality improvement programs and focus on reducing readmissions, within 30 days of discharge, for people admitted with a diagnosis of acute myocardial infarction, heart failure and pneumonia.

    Read More

  • Family Health Assessment Paper

    1897 Words  | 8 Pages

    She also was concerned if she needed to carry around an epi pen; we decided it was a prudent idea to have available at all times. Evaluation: N.H. was very surprised at all of the information that was provided to her. She did not realize the importance of her allergies, and was shocked by the seriousness. N.H. is now completely aware of her allergies, she can state detailed signs and symptoms, and is educated on how to appropriately treat them. She is also aware of triggers of her headaches, and methods she can employ to reduce the pain she experiences.

    Read More

  • Narrative Essay On Compare And Contrast Basketball And Simeon

    2306 Words  | 10 Pages

    I had asthma when I was a baby but it had went away. He told me I should go to the doctor and take a test to see if I have asthma . I went to the doctor and they told me that my asthma had came back and gave prescription to get my asthma pumps. After I got my asthma pumps I was back to normal with a lot of energy

    Read More

  • Food And Drug Administrations

    865 Words  | 4 Pages

    Daily millions of products come into the U.S. and the FDA inspects those products to protect the consumer from biological or radiation materials that pose a threat to lives. Every pharmaceutical company within the U.S. must meet the standards set by the FDA before patenting and selling their drugs. The actual process can take up to several years. Public health is the focus of the FDA and regulations and mandates changes constantly to meet the needs of the American

    Read More

  • Bio 3800 Unit 1 Writing Assignment

    837 Words  | 4 Pages

    Is sneezing, coughing, hives just to mention a few, part of the allergies? 2. Do you have any pets in your

    Read More

  • Informative Speech On Allergen Immunotherapy

    868 Words  | 4 Pages

      I would like to start off with what is probably the most important aspect, what allergen immunotherapy is.   According to Allergy, Asthma, and Immunology Research, Allergen Immunotherapy was a treatment created by Leonard Noon in 1911. It consists of allergy shots that trigger the immune system just enough without causing anaphylaxis. Anaphylaxis, or anaphylactic shock, is a serious allergic

    Read More

  • Peanut Allergy: A Short Story

    1041 Words  | 5 Pages

    When my friends ask if I want to try some of their food, I must always question, “Do you know what’s in it? Are there any nuts?” Hence I am so vigilant of what I put into my body, I have never had an instance where I had to use my EpiPen, which is a very good thing. Not only does my family feel more secure knowing that I was taught well enough to stay out of harm’s way, but it makes me feel better about myself that at such a young age, I am able to look after myself. Though it is hard to have such a severe allergy, I have made the most out of what I possibly

    Read More

  • Benefits Of Mandatory Vaccination

    1557 Words  | 7 Pages

    Is mandatory vaccination really necessary? Experts around the world collectively say 'Yes '. Mandatory vaccinations have proven, several times throughout history, to be incredibly helpful and at times crucial to the well-being of the human race. Mandating certain vaccines has saved entire nations from disaster and defeat. The lack of vaccinations and medical treatment for some viruses has wiped out populations as a whole.

    Read More

  • Informative Essay On Allergies

    606 Words  | 3 Pages

    Every year, all around the world, people 's lives are drastically effected by allergies. Usually, these people do not know what measures to take, in order to control their symptoms. You do not have to worry about this because, in the following article, you are going to be given advice that will allow you to live comfortably with allergies. For allergy sufferers who are especially sensitive to common allergens, it is important to reduce or entirely avoid using the hands to touch their faces. Surface allergens are easily transferred from the fingers to delicate areas like the mouth, eyes and nasal area.

    Read More

  • Nursing Case Study Asthma

    1025 Words  | 5 Pages

    Imelda’s father breeds dogs and he is also a smoker. This would impact on the air in the home which is noted in the symptoms that the smoke and dogs could make her asthma worse. Imelda has had exacerbations recently. Imelda needs a lot of medications including long term oral steroids, prevented inhaler and a blue inhaler however she has not refilled her prescription for these I the last month, which would cause concern for the management of Imelda’s asthma of the impact that this would have on her physically need.

    Read More

  • Allergic Synthesis

    1339 Words  | 6 Pages

    For this to occur, B cell receptor activation by the antigen, the presence of a Th2 cytokine environment (IL-4), and signaling through CD40 is required (REF). Although these signals can be provided by T cells, T cell-independent class switching has also been described, where other cells including basophils and mast cells take on this role. The resulting antigen-specific IgE is a key player in the second phase of allergic inflammation, and therefore also a therapeutic target. Secreted locally in tissue and systemically in peripheral blood, IgE molecules are captured by IgE receptors on a variety of cells. Two types of IgE receptors exist.

    Read More

More about Omalizumab Research Paper

Open Document