Physico-Chemical And Topographical Analysis

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PHYSICO-CHEMICAL, MORPHOLOGICAL AND TOPOGRAPHICAL CHARACTERIZATION OF MATERIALS INTRODUCTION: Biological evaluation and identification of the medical device is done by checking the three properties, they are Physicochemical, morphological and topographical . The evaluated data is used in a) Assessing the overall biological evaluation of a medical device (ISO 10993); b) Screening of potential new materials and/or processes for suitability in a medical device for a proposed clinical application. The compositional characteristics of the materials of manufacture are mainly under the control of the suppliers of these materials. However, other characteristics are chiefly influenced by the requirements to be met by the finished medical device as well as the production processes used by the medical device manufacturer. …show more content…

However there are several examples of where these relationships are becoming better understood, as listed below. 1) The use of certain PMT characteristics of porous materials as surfaces on orthopedic implants can encourage tissue in-growth at the surface of the implant and thus result in better integration with the surrounding tissue. 2) The use of material scaffolds and meshes, with certain PMT characteristics, as implants into injured soft or hard tissue can facilitate the beneficial infiltration of certain types of cells which aid the healing process 3) The PMT characteristics of the surfaces of materials used as catheters have a major influence on the adherence of bacteria and proteins to the inner and outer surfaces, which in turn influences the risk of infections and blockages. 4) Alterations to the micro-topography of surfaces, e.g. producing microgrooves or other defined patterns, have been shown to influence the adhesion and direction of movement of certain types of cells on that

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