Design and Characterization of Orodispersible Tablet of Ketorolac Tromethamine RESULT AND DISCUSSION Ketorolac Tromethamine is a potent NSAID agent with moderate bioavailability with highly bitter in taste. We have found that MDT technology will be better to improve bioavailability and taste masking of the selected drug. MDT tablet will releases their contents rapidly for immediate onset of action, to prevent its first pass metabolism, and to improve bioavailability. It also leads to reduction of dose and drug toxicity, which lead to improve patient compliance The solubility of Ketorolac tromethamine was determined in different solvent systems and buffers The IR spectra of physical mixture of polymers and drug were shown in Figure 4.8.
The end product was passed via sieve (no. 85) and stored in desiccators until use. 2.3. Preparation of DS loaded mucoadhesive beads PC-SA [F0], DS-SA [F1] and DS-PC-SA [F2-F6] beads were prepared by the ionotropic gelation method and the compositions are summarized in Table 1. Initially, PC gum was dissolved in distilled water and boiled for 10 min, cooled and stirred for 24 h at
Formulation of topical gel containing plant extract  20 g gel was prepared by simple dispersion method. Different concentrations of Carbapol 934 were used to prepare the formulation. Required amount of Carbapol and adequate amount of purified water was taken in a beaker. It was mixed to get a uniform mixture using magnetic stirrer and kept overnight for swelling. 1 ml of the extract and Piperine was dissolved in ethanol and added to the polymer solution along with propylene glycol and methyl paraban with gentle stirring.
Acetone: Acetone dissolves many hydrophilic and lipophilic components, is miscible with water, is volatile and has a low toxicity, it is a very useful extractant, especially for antimicrobial studies where more phenolic compounds are required to be extracted. A study reported that extraction of tannins and other phenolics was better in aqueous acetone than in aqueous methanol (Das K et al.,2010, Eloff JN.,1998) . Both acetone and methanol were found to extract saponins which have antimicrobial activity (Ncube
Esomeprazole magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through the inhibition of H+/K+ ATPase in gastric parietal cell. Esomeprazole is the S-isomer of omeprazole. The present study was an attempt made to formulate and evaluate esomeprazole enteric coated matrix pellets by Extrusion and Spheronization method using HPMC, Xanthan gum as control release polymers. Pellets are filled in the enteric coated capsules which were not disintegrated in stimulated gastric fluid. But the first units which disintegrates and produces the minimum effective concentration when the study was continued in phosphate buffer pH 6.8 and further the second units which is prepared by controlled release polymer disintegrated and produce
The flask was then vented. The shaking and venting of the flask was further repeated several times to remove as much CO2 from the soft drink sample as possible. Now the 100 mL beaker was taken and 10.0 mL of the soft drink was measured into it. To this 100 mL beaker, 25 mL of distilled was
The sample was made into powdered followed by added with IR grade potassium bromide powder weight ratio of 1:100 then get triturated. Thereafter the pellet was prepared to press using a hydrostatic press at a pressure of 10 tons for 5 min. The prepared pellet was fitted in the sample holder and scanned from 4000 to 400 cm-1 at a resolution of 4 cm-1. 2.9. Differential scanning calorimetry (DSC) The DSC curve of pure DS, PC, PC-SA beads and DS loaded PC-SA combined beads were recorded using a Perkin Elmer instrument (Pyris, DSC 600, Japan).
Secondly, the obtained blend was uniformly spread as a homogeneous layer on the surface of the mortar and left standing for five minutes to allow the liquid medication to be absorbed inside powder particles. Thirdly, the powder was scraped from mortar surface by means of a spatula and blended with a calculated quantity of superdisintegrant 5% (w/w) for 10 minutes. Sodium starch glycolate (SSG) was used in the all liquisolid formulations, then the final mixture was lubricated with 1% magnesium stearate for two minutes. Lastly, the prepared formulations were compressed manually into cylindrical tablets by using a single punch tablet press machine of die sizes measuring 6 and 8 mm. The optimized formulation with optimal R value, drug concentration and loading factor was determined according to the flow properties and in-vitro dissolution studies.
The eggs were divided into 5 groups, each treatment was done in triplicates. Calamansi crude extract was reconstituted to three concentrations: (Treatment 1, 99μ of distilled water and 1μL of Calamansi crude extract) 1%, (Treatment 2, 95μ of distilled water and 5μL of Calamansi crude extract) 5%, and (Treatment 3, 90μ of distilled water and 10μL of Calamansi crude extract) 10%. Retinoic acid was used as a positive control, and ethanol as negative control. Approximately, 100μL of each treatment was placed in the filter paper. After the introduction of test solutions, the eggs were sealed with a tape and incubated for