2.1. Determination of Angle of Repose Angle of repose was measured using a fixed height funnel fitted at the height of 10cm from the base .20g of the dried granules was allowed to flow through the funnel in to the base and a pile was formed at base .The angle of repose was calculated as follows:
Angle of repose = tan-1(h/r) where h and r are the height and radius of the pile respectively. 2.2. Bulk Density It is the ratio of mass and bulk volume. It is required to decide the appropriate packing of dosage forms 20g of the dried granules was allowed to flow in a fine stream in to graduated cylinder and final was noted. The bulk density was obtained by dividing the weight of the sample in grams by final volume in
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In all the formulations the amount of Paracetamol was kept constant at 250 mg and the gum was used in different ratios 10%, 20%, 30%,40%,50% respectively Albizia Stipulata gum ,Prunus Cerasoide gum,Xanthan gum,HPMC …show more content…
Final weight of 20 tablets measured after the complete rotation of machine. The weight variation after friability is less than 1 %. 4.3. Weight Variation: To study weight variation individual weights (WI) of 20 tablets from each formulation are noted using electronic balance. Their average weight (WA) was calculated. Percent weight variation was calculated. Average weights of the tablets along with standard deviation values were calculated.% weight variation = (WA–WI) x 100/ WA The weight variation between tablet ± 5 5. In-Vitro Drug Release Study The drug release study was performed by using type II dissolution apparatus (paddle type) in which phosphate buffer PH 5.8 at rotation speed 50 rpm and the temperature of the bath was maintained at 37.0+0.50C. The volume of the dissolution medium was kept 900ml and after a specified period of time 5ml of sample were taken and filtered by using whatman filter paper size no 1 ,after a filtration diluted with 500 micro liter in 10ml dissolution medium then analyzed quickly in UV double beam spectrometer at 243 nm. After each withdrawal same amount of dissolution medium was added to maintain the volume of the bath up to 900ml and continued the process further with same
Therefore, liquid-liquid and acid-base extraction techniques were successfully performed to separate the components of the Excedrin tablet. According to the TLC analysis results, the compounds (aspirin, acetaminophen, and caffeine) were successfully isolated from the analgesic (Excedrin tablet). In figure 1, the separation of the compound in the TLC analysis correlates with the TLC analysis in figure 2. Furthermore, Rf index calculations of the TLC analysis demonstrated that the compounds (aspirin, acetaminophen, and caffeine) were separated. The Rf calculations of aspirin in table 1 shows an Rf value of .491; however, in table 2 the Rf value of aspirin was calculated to be .784.
Also, the tablets could pose an error if they aren’t the same size or broken. The tablets used should not be broken, and they should be weighed before each
Introduction: Quetiapine Fumarate (QF) is a psychotropic agent indicated for the treatment of schizophrenia and manic episodes associated with bipolar disorder. QF possesses good solubility in aqueous fluids (1) and ethanol. Quetiapine is available in the market with the brand name of Seroquel XL (2). Inadvertent, rapid drug release in a small period of time of the entire amount or a significant fraction of the drug contained in a prolonged release dosage form is often referred to as “dose dumping”. Jhonson F. et al.
The spatters were given time to dry. 8. The diameter of each spatter was measured in mm. 9. The results were recorded.
Molar Relationships: What Are the Identities of the Unknown Compounds? The purpose of the experiment was to identify unknown compounds using knowledge on the concept of mole. The guiding question for this experiment is what are the identities of the unknown compounds? The numbers of moles and the identities of the compounds are the only given. To be able to identify the compounds the mass, molar mass and the number of moles will be needed.
Wt. Mass Density Appearance 2-methycyclohexanol 0.75 mL 114.19 g/mol 0.93 g/mL Clear colorless liquid 85% Phosphoric acid 1.00 mL Clear
s q. s q. s q. s q. s q. s Table no.1 Formulation Table Table No.2: Physicochemical properties of the prepared buccal patches of Metoprolol Tartrate Formulations Folding Endurance* Tensile Strength* (%) Percentage Elongation* (%) Percentage Moisture absorption* (%) Percentage Moisture loss*(%) Drug Content* (%) F1 315 ± 2.516 38.72±1.10 143±1 3.89±0.67 1.5±0.82 91.64±1 F2 326 ± 2.081 46.71±1.505 122±1 4.19±0.75 1.4±0.97 94.60±1.174 F3 328 ± 2.645 42.43±0.735 121±1 5.11±0.94 2.1±0.65 93.25±0.960 F4 318 ± 1.527 49.34±1.01
In particular, the formulation of rosuvastatin, molecule which is generally lipophilic, poses real problems owing mainly to their low solubility in aqueous liquid pharmaceutical excipients, to their propensity to precipitate or recrystallize in aqueous solution and to their low solubility in the fluids of the gastrointestinal tract from which they must be absorbed. The bioavailability of an active ingredient also depends on its concentration in the gastrointestinal fluid, said concentration itself being dependent on the release of the active ingredient. In particular, the more lipophilic an active ingredient is, the less tendency it has to migrate in gastrointestinal fluids.
The purpose of this experiment is to assess which type of analgesic, over the counter, medication will have a significant impact on the stomach pH. Many people use nonsteroidal anti-inflammatory drugs (NSAIDs) primarily to treat inflammation, relieve pain, etc. Analgesic medications such as Naproxen Aleve, Motrin 800, Nuprin Advil, and Tylenol utilized in this experiment are widely used by the community to treat headaches, menstrual cramps, arthritis, injuries, etc. The most prevalent side effects are vomiting, nausea, diarrhea, drowsiness, and headache. Since these analgesic drugs upset the stomach, they presumably acidify the stomach pH. Occasionally, some of the stomach acid could escape into the esophageal. Due to the fact that the esophagus
Leah Romero 10/30/2017 Conclusion Lab 3 Chem 102L In lab 3, fundamentals of chromatography, the purpose was to examine how components of mixtures can be separated by taking advantage of different in physical properties. A huge process in this lab was paper chromatography, which was used to isolate food dyes that are found in different drink mixes. The different chromatograms of FD&C dyes were compared to identify which dyes are present in each of the mixes.
Like how the temperature affected how long it took for the tablet to react to the water, if there is only one drop water used to dissolve the whole tablet, the time it takes for the whole tablet to react to the water and start to dissolve will be
We zeroed out the scale and weighed all four potato cores at once and recorded the mass. We then put those potato cores into the beaker of 75 mL of solution. With the potato cores in the beaker we then put a watch glass over the top of the beaker to minimize the amount of solution that evaporates. We let the potato cores sit in the solution overnight. The next day we then emptied the beaker of the solution by carefully draining the solution, while not letting the potato cores fall out.
(Molarity)(Volume)(Molar mass) The pellets were dissolved thoroughly then was used in filling up the 100 mL volumetric flask. The solution was mixed well
Biochemical tests are the tests used for the identification of bacterial species based on the differences in the biochemical activities of different bacteria. Bacterial physiology differs from one species to the other. These differences in carbohydrate metabolism, protein metabolism, fat metabolism, production of certain enzymes and ability to utilize a particular compound help them to be identified by the biochemical tests. Gram’s stain was originally devised by histologist Hans Christian Gram in 1884. Gram-positive bacteria stain purple, while Gram-negative bacteria stain pink when subjected to Gram staining.
Introduction Buffer is a solution that resists a change in pH when bases or acid are added. Solutions that are acidic contain high concentrations of hydrogen ions (H+) and have pH values less than seven. Buffer usually consist of a weak acid, and its conjugate base or a weak base and its conjugate acid. The function of buffer is to resist the changes in hydrogen ion concentration as a result of internal and environmental factor. This buffer experiment is important so that we relies the important of buffer in our life.