Paracetamol Tablets Lab Report

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2.1. Determination of Angle of Repose Angle of repose was measured using a fixed height funnel fitted at the height of 10cm from the base .20g of the dried granules was allowed to flow through the funnel in to the base and a pile was formed at base .The angle of repose was calculated as follows:
Angle of repose = tan-1(h/r) where h and r are the height and radius of the pile respectively. 2.2. Bulk Density It is the ratio of mass and bulk volume. It is required to decide the appropriate packing of dosage forms 20g of the dried granules was allowed to flow in a fine stream in to graduated cylinder and final was noted. The bulk density was obtained by dividing the weight of the sample in grams by final volume in …show more content…

In all the formulations the amount of Paracetamol was kept constant at 250 mg and the gum was used in different ratios 10%, 20%, 30%,40%,50% respectively Albizia Stipulata gum ,Prunus Cerasoide gum,Xanthan gum,HPMC …show more content…

Final weight of 20 tablets measured after the complete rotation of machine. The weight variation after friability is less than 1 %. 4.3. Weight Variation: To study weight variation individual weights (WI) of 20 tablets from each formulation are noted using electronic balance. Their average weight (WA) was calculated. Percent weight variation was calculated. Average weights of the tablets along with standard deviation values were calculated.% weight variation = (WA–WI) x 100/ WA The weight variation between tablet ± 5 5. In-Vitro Drug Release Study The drug release study was performed by using type II dissolution apparatus (paddle type) in which phosphate buffer PH 5.8 at rotation speed 50 rpm and the temperature of the bath was maintained at 37.0+0.50C. The volume of the dissolution medium was kept 900ml and after a specified period of time 5ml of sample were taken and filtered by using whatman filter paper size no 1 ,after a filtration diluted with 500 micro liter in 10ml dissolution medium then analyzed quickly in UV double beam spectrometer at 243 nm. After each withdrawal same amount of dissolution medium was added to maintain the volume of the bath up to 900ml and continued the process further with same

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