Pcl Research Paper

5.0 PROPERTIES

5.1 PROPERTIES OF PCL

5.1.1 Mechanical properties

MECHANICAL PROPERTIES DESCRIPTION

i. Density 1.1 g/cm3 (69lb/ft3) ii. Elastic (Young’s Tensile) Modulus 1.2 GPa (0.17 x 106 psi) iii. Elongation at Break 300 % iv. Glass Transition Temperature -60 °C (-80 °F)

v. Melting Onset (Solidus) 60 °C (140 °F) vi. Strength to Weight Ratio 9 kN-m/kg vii. Tensile Strength: Ultimate (UTS) 10 Pa (1.5 x 103 psi)

5.1.2 Solubility

PCL is soluble in chloroform, dichloromethane, carbon tetrachloride, benzene, toluene, cyclohexanone and 2-nitropropane at room temperature. It has a low solubility in acetone, 2-butanone, ethyl acetate, dimethylformamide and acetonitrile and is insoluble in alcohol, petroleum ether and diethyl ether.

5.1.3 Biodegradable

The first phase follows a first-order linear pattern, in which the initial mass and volume of the microspheres are undamaged. During this phase, the average length of the polymer chain in the microspheres continuously decreases with time via chain scission according to the kinetic law (with k being the average rate constant for chain scission). While for the second phase, its starts at a specific chain length and was characterised at the beginning or onset of volume and total mass loss via bioresorption. Different from other degradable dermal fillers, the non‑toxic oligomers resulting from total bioresorption of the Ellanse microspheres are completely excreted through normal metabolic pathways into CO2 and H2O.

5.2.2 Tunable longevity

It is duration of clinical performance which can be modified by adjusting the initial PCL formula. The basis of unique Ellanse dermal filler family is, it was differentiated by the initial polymer chain length which resulting in offering tunable longevity. This has led to the creation of the new and innovative products in the Ellanse family with different clinical effectiveness; Ellanse-S (1 year), Ellanse-M (2 years), Ellanse-L (3 years) and Ellanse-E (4