Pemberian Air Masalah Case Study
Pengaruh pemberian air rebusan meniran (Phyllanthm niruriLinn) terhadap gambaran histopatologi hepar tikus wistar yang terinduksi Paracetamol dosis toksik BAB I Pendahuluan 1.1 Latar Belakang Masalah Parasetamol (acetaminophen) adalah analgesik ringan yang banyak digunakan di masyarakat luas. Paracetamol merupakan metabolit fenasetin dengan efek antipiretik yang ditimbulkan oleh gugus amino-benzen. Namun efek anti inflamasi paracetamol hampir tidak ada. Hal ini disebabkan Parasetamol bekerja pada tempat yang tidak terdapat peroksid sedangkan pada tempat inflamasi terdapat lekosit yang melepaskan peroksid sehingga efek anti inflamasinya tidak bermakna. Parasetamol memiliki nama lain (N-asetil- p.aminofenol) [C8H9NO2] berguna …show more content…
Metabolit ini kemudian dieksresikan ke ginjal. Sejumlah kecil (5-10% dari dosis terapeutik) dimetabolisis hepar melalui sistem 2 enzim cytochrome P450 (khususnya CYP2E1). Efek toksik parasetamol sebenarnya hanya terkait dengan sebuah metabolit alkil minornya yaitu N-acetyl-p-benzo-quinone imine (NAPQI). Jadi, efek toksik yang muncul bukanlah karena parasetamol itu sendiri atau metabolit utamanya. Pada dosis yang lazim digunakan, metabolit toksik NAPQI secara cepat didetoksifikasi melalui kombinasi irreversible dengan gugus sulfhydryl dari glutathione, menghasilkan konjugasi non toksik yang akhirnya dikeluarkan melalui …show more content…
1.3 Tujuan Penelitian 1.3.1 Umum Mengetahui Pengaruh Pemberian Air Rebusan Meniran (Phyllanthm niruriLinn) Terhadap Gambaran Histopatologi Hepar Tikus Wistar yang Terinduksi Paracetamol Dosis Toksik. 1.3.2 Khusus i) Untuk mengetahui pengaruh pemberian air rebusan meniran (Phyllanthm niruriLinn) pada tikus wistar yang terinduksi Paracetamol berbagai dosis. ii) Untuk mengetahui pengaruh pemberian air rebusan meniran (Phyllanthm niruriLinn) terhadap gambaran histopatologi hepar tikus wistar yang terinduksi Paracetamol berbagai dosis. iii) Untuk mengetahui pengaruh pemberian air rebusan meniran (Phyllanthm niruriLinn) terhadap gambaran histopatologi hepar tikus wistar yang terinduksi Paracetamol dosis toksik. 1.4 Manfaat Penelitian Manfaat yang diharapkan dari penelitian ini antara lain: 1.4.1 Manfaat teoritis Bermanfaat untuk menambah khasanah pengetahuan mengenai pengaruh pengaruh pemberian air rebusan meniran (Phyllanthm niruriLinn) terhadap gambaran histopatologi hepar tikus wistar yang terinduksi Paracetamol dosis toksik. 1.4.2 Manfaat
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