INTRODUCTION Peptic ulcers are also known as “ulcus pepticum”. An ulcer is defined as a non malignant mucosal lesion of the stomach. It occurs due to exposure of stomach and duodenum to pepsin and gastric acid. Peptic ulcer is due to imbalance occurs between aggressive factors like acid, pepsin, H. pylori and defensive factors such as gastric mucus, nitric oxide and growth factors bicarbonate ions and prostaglandins, mucosal blood1. Local mechanisms implicated in mucosal defence are mucus-bicarbonate secretion, mucosal hydrophobicity, rapid epithelial cell restitution and rich mucosal blood flow2. Peptic ulcer disease (PUD) encompassing gastric and duodenal ulcers. It is the most prevalent gastro intestinal disorder and has been a major threat to the world’s population over the past 2 centuries, with a high morbidity and substantial mortality3. Some psychological conditions like anxiety, stress, surgical shock, burns, trauma, free radicals, oxidants, physical, chemical factors also stimulate gastric acid secretion and leads to ulcer4. Prostaglandins E2 and I2 are the predominant prostaglandins synthesized by the gastric mucosa and are known to inhibit the secretion of gastric acid and stimulate the secretion of mucus and bicarbonate5. Peptic ulcer diseases comprise heterogeneous disorder which manifests as a break in the …show more content…
The volume in the test tube was adjusted to 0.1 ml with appropriate buffer. Five milliliters of protein reagent was added to the test tube and the contents were mixed either by inversion or vortexing. The absorbance at 595 nm was measured after 2 min and before 1 hr in 3 ml cuvettes against a reagent blank prepared from 0.1 ml of the appropriate buffer and 5 ml of protein reagent. The weight of protein was plotted against the corresponding absorbance resulting in a standard curve used to determine the protein in unknown
In Jay Hardy article, “Medical Wisdom Challenged by a Cocktail” analyzes the discovery of the real cause of gastric ulcers. Also, he talked about Marshall’s struggle trying to prove his theory in an outrageous way. Most scientists thought the cause of stomach ulcers before Warren and Marshall’s discovery were stress, excess acid, and eating spicy food. However, German scientists researched that a spiral-shaped bacterium inhabited that was lining of the human stomach, but they couldn’t culture the organism. So, the research on stomach ulcers were forgotten.
Crohn 's is an immune-mediated inflammatory disease that belongs to a larger group of illnesses called inflammatory bowel disease (IBD). It is associated with inflammation of the digestive tract, or gastrointestinal (GI) tract, which runs from the mouth to the anus, and includes the stomach and intestines. It more commonly affects the end of the small intestine and the large intestine. Crohn 's disease symptoms and complications are unpredictable , you may experience almost no symptoms, then have a sudden flare-up. Or you could experience symptoms every day Crohn 's disease is difficult to diagnose, because symptoms vary and because it can be similar to other conditions.
The thing that I’m most activity involved in a positive way is also the thing that has been the most negative thing in my life. When I was a freshman in high school I got diagnosed with Crohns. You might be wondering how an event can be both a positive and a negative thing in my life. I spent along time dealing with that exact question. I finally came up with an answer, the reason it’s both positive and negative… before I tell you that let me explain a few things.
Helicobacter Pylori is typically found in the epithelial lining of the stomach or in the gastric mucous layer frequently adapting to the tough environments of the stomach. Humans are the target reservoir for this bacterium to infect. It is a spiral shaped, gram-negative bacterium that causes gastric and duodenal ulcers in the stomach. Helicobacter Pylori was first discovered in 1982 when two biologists took a brand new bacterium, isolated it, and showed that the bacterium caused ulcers in the stomach. The link between bacteria and ulcers was then established.
INTRODUCTION Pressure ulcers are a serious and common problem for older individuals, affecting nearly 1 million adults in the United States. As the population ages, pressure ulcers will remain as a major health care problem. Generally, a pressure ulcer can be defined as any injury caused by unrelieved pressure that results in damage to underlying soft tissue when the tissue is compressed between a bony prominence and external surface over an extended period of time. With aging, local blood supply to the skin reduces, epithelial layers flatten and thin, subcutaneous fat decreases, and collagen fibers lose elasticity.
When I was first diagnosed with ulcerative colitis, a common colon disease, I had no idea what it was. It wasn’t until several tests and explanations from multiple doctors that my parents and I started to understand the extent of the problem. Although it didn’t seem like it would be a big deal, it quickly took over my entire life. Dealing with the condition meant chronic pain, medication, and many more doctors’ visits. Fortunately, my case wasn’t too severe.
Keratosis Pilaris (KP) is a common, benign, genetic disorder of the skin affecting nearly 50-80% of adolescents and 40% of adults, with females being more affected than males (Alai 2011). The condition is more common during childhood and adolescence as it can be exacerbated by puberty and hormonal changes. KP is due to a faulty process of keratinization, in which there is an excessive formation and buildup of keratin in the hair follicles of our skin (Alai 2011). This buildup creates small, rough and dry bumps on specific areas of the body, the most common areas being the upper arms, thighs and buttocks.
Introduction: Helicobacter pylori are a ubiquitous organism that can be seen in 50% of general population. Its association with various gastric disorders are well established in numerous studies after its discovery in 1983. Peptic ulcer disease is the most studied disease related to H Pylori infection. H. pylori are seen in 90% of duodenal ulcer and 75% of gastric ulcer Patients. This bacterium is also involved in the pathogenesis of several extra gastric diseases, such as mucosa-associated lymphoid tissue lymphomas ( Maltomas) gastroesophageal reflux disease ( GERD ) and gastric carcinomas.
Question 1. Recognition of the predisposing factors that have contributed to Elsie’s pressure ulcer development. (4 marks) • Age: Individuals that are beyond the age of 75 are at an increasing risk of developing a pressure ulcer, due to the decrease in functioning macrophage which results in the delay of inflammatory response, collagen synthesis and slower epithelialisation. (Potter, Perry, Stockert & Hall, 2015) • Nutritional status: Individuals who are receiving an inadequate level of nutrients are at a more vulnerable state of developing pressure ulcers as having an inadequate level of nutrient prevents effective cellular growth and repair. Koutoukidis, Stainton, Hughson & Tabbner, 2013) • Mobility: Individuals who have a reduced or modified mobility find it difficult to move
Author(s): Michael J. G. Farthing Source: BMJ: British Medical Journal, Vol. 310, No. 6973 (Jan. 21, 1995). Irritable bowel syndrome Author(s): Alexander C Ford and Nicholas J Talley Source: BMJ: British Medical Journal, Vol. 345, No. 7873 (8 September 2012).
Diverticulitis This sporadic disease can be somewhat mysterious, which sparks curiosity for further investigation. Diverticulitis, one of many detrimental diseases, stuck out particularly because of its unusual complications and possible deadly side effects. Out of millions of diseases, what astounding traits make this one so common? The three main ideas that are meant to be covered are: The components that make diverticulitis a problem, the action that may be taken to treat or prevent, and finally what makes this a gateway disease to other health problems. If actions are not taken quickly, the results may end up fatal.
Gastritis: Gastritis is the is soreness of the stomach facing due to a mass of feasible cause with Helicobacter pylori infection being with the principal causes. It tends to be longer durable than gastroenteritis with chronic infectious gastritis long term for months or yet
The digestive system is made up of the gastrointestinal (GI) tract and the liver, pancreas, and gallbladder. The GI tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus. The hollow organs that make up the GI tract are the mouth, esophagus, stomach, small intestine, large intestine (which includes the rectum) and anus.5 Food enters the mouth and passes to the anus through the hollow organs of the GI tract. The liver, pancreas, and gallbladder are the solid organs of the digestive system. The digestive system helps the body digest food.
Next, a basic stock solution was used to prepare various concentrations ranging from 1.0 x 10-8M to 1.0 x 10-1M by serial dilution. The tissue was washed by overflow with reservoir’s solution for 5 seconds to obtain baseline before adding 0.1ml, 0.3ml and 0.5ml for each concentration respectively into the tissue bath. The tissue’s peak response for each final bath concentration(FBC) was measured and recorded. Rmax and EC50 of histamine were recorded.
This study has shown that some intestinal cells express RAGE which is responsible for absorption of oxytocin from the gut into the blood. Therefore, oxytocin is ingested by a specific molecular mechanism, and it can be orally administered as a medication and a