Periodontal Therapy Essay

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INTRODUCTION The major goals of periodontal therapy includes elimination of infection and controlling inflammation in order to arrest the progression of disease, and also the regeneration of lost tissues. Various biomaterials have been used for the treatment of intrabony defects and have demonstrated variable results [1]. Recently, biological modifiers (growth factors) demonstrated their ability to stimulate cells which are located in periodontal defect and resulted in proliferation and differentiation of periodontal ligament cells [2]. Biological modifiers are materials or proteins that have the potential to modify the host tissue so as to enhance wound healing process. These growth factors comprise platelet derived (PDGF), insulin…show more content…
Platelet rich fibrin (PRF) belongs to second generation platelet concentrate was first developed in France by Choukroun et al. [4] This protocol does not require the addition of an anticoagulant or bovine thrombin. This technique makes it possible to collect a fibrin clot enriched with serum and platelets [5]. The natural fibrin clot in PRF seems responsible for a slow release of growth factors for an extended period [6]. The viable platelets in PRF release six important growth factors like, Platelet-derived (PDGF), Vascular endothelial growth factor (VEGF), Transforming growth factor (TGF), Insulin growth factor-1 (IGF), Epidermal growth factor (EGF) and Fibroblast growth factor (bFGF). Because of its strict autologous nature, extended growth factore release and cost effectiveness, PRF has shown superior clinical result compared to platelet rich plasma (PRP -first generation platelet concentrate). Considering the above facts, it would be expected that PRF may enhance the wound healing in intrabony defects. The purpose of this clinical study was to evaluate the effectiveness of PRF in promoting clinical parameters in human intrabony defects and to assess the ability of Demineralized bone matrix graft (DMBM) to enhance the regenerative effects of
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