CER Labs 2-3 Figure 1. Friedel-Crafts Acylation. Claim: An acetyl group was efficiently introduced to ferrocene by Friedel-Crafts Acylation (Figure 1). We isolated our crude yield while comparing 2 purification techniques: column chromatography and recrystallization. TLC, NMR, and IR spectroscopy were used throughout the process to identify ferrocene and acetylferrocene in addition to evaluating the levels of purity.
He also delivered the results of enzymatic hydrolysis, hydrolysis, and acetolysis with acetyl bromide pattern of dextrins. During this time, other researchers confirm the cyclic structure of dextrins by X-ray crystallography [34, 35]. In 1948, his group discovered γ-dextrin and elucidated its structure . He suggested for the first time, the hydrophobicity of inner cavity in dextrins
There is the need to have defined measures put in place so as to facilitate the production process which will make it successful. Lorex Pharmaceuticals has a new business venture that needs to be addressed and its success will be dependent on how well the organization will manage to define an approach that will best suit the company. In the market, the rate of production is determined by the demand that is available. When there is high demand for the drug, it will be possible for the company to increase its production of the
ETD is a white crystalline compound. Dimethyl sulfoxide, and aqueous polyethylene glycol. In-situ gel forming systems have been widely investigated as vehicles for sustained drug delivery. They can be defined as “the solution of polymer that forms gel in-situ due to one or combination of different stimuli like pH change, temperature modulation and solvent exchange, known as the in-situ gels”. Gastro retentive system is a drug delivery system that delivers drug and remains within the gastric region for longer duration of time.
Spectrophotometric methods are described in this paper, the simultaneous determination of paracetamol and ibuprofen using derivatives of the ratio spectra method (Yousry M., 2011), and the determination of Ibuprofen using difference spectroscopy (Hapse S.A, 2011). The objective of this work is to use these methods to establish a straight-forward, rapid and precise method in the analysis of Ibuprofen for undergraduate laboratory practical’s. The second aim of this work is to establish a method to separate pharmacologically active components in over-the-counter medication by solvent extraction. The chosen medication, Excedrin®, contains three active components, aspirin, acetaminophen and caffeine, and a binding material. One tablet contains 250mg of aspirin, 250mg of acetaminophen and 65mg of caffeine.
Amorphization of Indomethacin tablets through microwave radiation 1. Introduction Biopharmaceutical classification system Class I High solubility High permeability Class II Low solubility High permeability Class III High solubility Low permeability Class IV Low solubility Low permeability A majority of the active pharmaceutical ingredients (APIs) in the research and development have poor aqueous solubility. However, the poor dissolution rate characteristic of relatively insoluble BCS class II substances has long been a problem for the pharmaceutical industry. When an insoluble or poorly soluble drug is orally administered, the rate and extent of absorption is controlled by the dissolution rate in the gastro-intestinal fluids. The oral bioavailability of these drugs are usually low due to the low water solubility and these formulation types will therefore give an unsatisfactory therapeutic effect by delaying the rate of absorption and onset of effect.
Alexion Pharmaceuticals was established in the United State in 1992 by the founder Leonard Bell and became a public company in 1996. Alexion Pharmaceutical is a global biopharmaceutical company focused on developing and delivering life-transforming therapies for patients with devastating and rare diseases. It is an American pharmaceutical company best known for its development of Soliris, a drug used to treat the rare disorders atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH). The company also involved in immune system research related to autoimmune diseases. The global headquarters and research operations are in New Haven, Conn. Alexion's approximately 3,000 employees around the world serve patients in 50 countries (Alexion.com).
These characteristics allow us to produce drugs, agroproducts and fine chemicals. STRUCTURE The lipases are found in nature. There are many types of lipases. In common most of the lipases are having an alpha or beta hydrolase folding addition to it they also have chymotrypsin like catalytic activity. PHYSIOLOGICAL DISTRIBUTION: These lipase enzymes have a widespread biological activity in biological processes from usual metabolism of dietary triglycerides to signalling pathways and inflammatory mechanisms.
Unknown A Y = 0.5377(0.641) Y = 0.345 mg/ml Unknown B Y = 0.5377(0.348) Y = 0.187 mg/ml Discussion After obtaining the results from the standard curve which was drawn up from the calculations of concentration and the absorbance from the spectrophotometer, seeing as the correlation coefficient was quite close to 1 (0.9368), this showed that there was a strong relationship between the concentration and absorbance of the proteins. However, the results for the unknown samples were not as accurate as they should have been, for Unknown A (0.345 mg/ml) was obtained where as it should have been closer to 0.5 mg/ml. For Unknown B (0.187) was obtained where as it should have been closer to 0.25mg/ml. There are a few reasons as to why the results did not come out as accurate as they should have, while weighing out the BSA for the stock solution. It wasn’t transferred to the volumetric flask for dilution as accurately as it should because it was washed down into the flask with de-ionized water, the whole
Analyze the brand revitalization / reinforcement / portfolio adjustment strategy of any India-based company Submitted by :Sreeraj R(WEB-103) Company Profile: The Himalaya Drug Company was founded in 1930. Vision: Bring Ayurveda to Public by selecting indigenous herbs and focus on formulations to modern pharmacological, toxicological to develop new drugs and therapies. Trademark Product: Serpina®, World’s first natural antihypertensive launched in 1934 The future course for Himalaya was based on this discovery. Based on the value of scientific research, continuous focus was laid on converting Ayurveda 's herbal tradition into a range of proprietary formulations to facilitate healthy living and longevity. Brand Building 1955:Himalaya introduced Liv.