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Summary: Background Of Suspension

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BACKGROUND OF SUSPENSION Suspension are probably the most challenging and difficult pharmaceutical formulation that need to be handle by the students and formulators. Pharmaceutical suspension is a liquid system that consist of solid material such as drug that do no dissolve in the vehicle, but just remain distributed throughout the vehicle. Pharmaceutical suspension fall across between colloidal and course dispersion with solid particle generally in the range 0.1 to 10um. Colloidal is a substance consisting of particles that are dispersed throughout another substance and are too small for resolution with an ordinary light microscope but are incapable of passing through a semipermeable membrane. Course dispersion Mostly drug are design in …show more content…

Where we have a charged surface, however, there must be a balancing counter charge, and this counter charge will occur in the liquid. The charges will not be uniformly distributed throughout the liquid phase, but will be concentrated near the charged surface. Thus, we have a small but finite volume of the liquid phase which is different from the extended liquid. The EDL is divided into two regions which are diffuse region and inner region. The diffuse region is the region where the ions are distributed according to the influence of charge (electrical force) and the thermal motion. The inner region also called as stern layer which includes specifically absorbed ions or molecules. These two part are separated by a stern plane. The stern layer is held closely to the surface. When a particle moves in the stern layer, other particle in the layer will move with it but particles beyond the stern layer do not move with it. The edge of diffuse layer is the shear plane (slipping plane). Shear plane is an imaginary surface that separating the solid and the liquid. There is electrical potential at the shear plane which is called as Zeta …show more content…

The stability is dependent upon the total potential energy function between them. This theory calculates the energies of attraction and repulsion between similar particles and predicts the overall energy of interaction. From this, we could estimate whether the particles coalesce and settle or remain evenly dispersed throughout the medium. To calculate the total energy interaction between two particles (VT), the value between energy of Van Der Waals attraction (VA) and the energy of electrical repulsion (VR) are summed as follow (VT = VA +

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