Pharmacogenetics In Pharmacogenomics

Pharmacogenetics indicates the study of variability in drug response due to heredity. Recently, with the adding of the suffix ‘… omics’ to indicate the areas of research, the term ‘pharmacogenomics’ has been introduced. Pharmacogenomics is a important factor to the pharmaceutical industry because it allows streamlining of the drug development, drug testing and drug registration process, reducing time from chemical synthesis to introduce it into clinical practice, and therefore the cost of the drug development process. Pharmacogenomics is the term which largely used in relation to genes determining drug metabolism, it is a broader based term that encompasses all genes in the genome that may determine drug response. The distinction however, is

Diseases are varied by person. Different types of disease are caused by different condition. For example, FCHL is disease that has a high total cholesterol, high LDL, high triglycerides and low HDL. Familial defective apolipoprotein B-100 is a disease that has high total cholesterol for such 350 to 550 mg/dL in total amount. Familial hypertriglyceridemia is a disease having very high triglycerides for such 200 to 500 mg/dL in total

There is a drug called statins in the market now which is also known as HMG-coA reductase inhibitors, prescribed for patients with elevated LDL levels. It is used to treat the high cholesterol by blocking the substances in the liver that produce cholesterol. Liver will then remove the cholesterol from the human blood. Besides, statins can absorb the excess cholesterol which had been trapped in human arteries. Usually, the ingredients in the statins include atorvastatin (Lipitor), fluvastatin (Lescol), rosuvastatin (Crestor), and simvastatin (Zocor). For those patients, who have history of heart attack or high risk for heart attack and high leverl of cholesterol, should be prescribed one of these medications. The statins have been shown in studies to reduce death from heart attacks in patients with a history of coronary artery