The melting point of the product from the bromination of aniline was 119.8-121.90c, which is in the range of the melting point of 2,4,6-tribromoaniline, 120-1220c, as indicated on PubChem, Open Chemistry Database (pubchem.ncbi.nlm.nih.gov). This verified the formation of the major products. Overall, one can say that the experiment was
2.2 Chemicals and reagents The API of AN (99.9% pure) 1000mg was purchased from market. HPLC grade acetonitrile (SD fine limited). Analytical grade hydrochloric acid ,sodium hydroxide flakes, hydrogen peroxide. Milli-Q Water purchased from market.. 2.3 Details of Method Chromatographic conditions: Reversed Phase High Performance liquid chromatography method with UV detection separation was achieved on zorbox Agilent Eclipsc XDB column c18(150 nm× 4.6 mm×5µm) as stationary phase with binary gradient mode solvent phase A. Composed of H3PO4(ortho phosphoric acid ) buffer ( pH ≈2, 0.02M) and phase B as Acetonitrile ,The Flow rate of the mobile phase was 1.0 mL/min and the total elution time including the column re-equilibration was approximately
Delamare  suggested that two different physical processes could have been involved in the formation of Egyptian blue crystals depending on the amount of the alkali included in the mixture. In the first, when alkali was added at the few percent level, a liquid or glass phase was formed from which the Egyptian blue crystals nucleated and grew. In contrast, when the alkali content was insufficient to produce a significant liquid or glass phase, the Egyptian blue crystals were formed by surface diffusion between the three components, that is, by solid-state sintering. Copper ions are the coloring agent; they are very tightly bound in the stable silicate matrix and cannot be removed easily by chemical and physical means, this tight binding is the key to the high stability of Egyptian Blue
DRUG AND EXCIPIENT PROFILE DRUG NAME: LOVASTATIN (LST) PHARMACOLOGICAL CATEGORIES: Lipid Lowering Agent Anti-Neoplastic Agent HMG-CoA Reductase Inhibitors. DESCRIPTION: It was discovered by Alfred Albert and his team in 1978 at Merck. It was isolated from fungus Aspergillus terreus and is also known as Mevinolin. This was the second compound identified of this class and is two times potent than the first discovered statin Mevastatin. Lovastatin (LST) is structurally similar to hydroxyl methylglutarate (HMG), a substrate of the cholesterol biosynthesis pathway and it differs by a methyl group only at single 6th position.
Figure 2. Representation of 1.3-butadiene (mw: 54.09 g/mol) Styrene: A colorless to yellowish liquid that produce polystyrene by homopolymerization. Styrene is a derivative of benzene and could be found in small quantities in plants and foods. It is slightly soluble in water and very soluble in ethanol, acetone and carbon disulfide. Its rate of polymerization is low at room temperature but increases at higher temperatures.
Lab Report 10: Nitration of Bromobenzene Raekwon Filmore CM 244 Section 40 March 27, 2018 Introduction: For this experiment, nitration of bromobenzene was the focus of the lab. The benzene is an aromatic compound and when it reacts with wither a mixture of sulfuric acid or nitric acid creates what is known as a nitro group. The formation of the nitro group is possible because it is an electrophilic aromatic substitution reaction. The creation of the nitronium ion is shown below: The reaction with the nitronium ion with bromobenzene creates three products instead of one. Depending on where the nitronium group or the alpha complexes of the reaction is on the ring, determines whether the product will be meta, para or ortho.
Sodium Nitrate is called Nitratine when it is in a mineral state. 3.3. USES OF SODIUM NITRATE Sodium Nitrate is used in manufacturing smoke bombs. The sample preserved in a small water bottle deformed the bottle and expanded it. This proves it is viable product in the manufacture of gun powder and smoke bombs.
The photolysis of the azirine with the shortwavelength light (>300 nm) caused the C-C bond cleavage of the 2H-azirine ring to produce the nitrile ylide.31 The C,C-dicyanoketenimines were generated by flash vacuum thermolysis of ketene N,S-acetals or by thermal or photochemical decomposition of alpha-azido-beta-cyanocinnamonitrile. In the latter reaction, 3,3-dicyano-2-phenyl-1-azirine 12 is also formed. Nucleophilic substitution reactions of 2-halo- 2H-azirines with potassium phthalimide and aniline allowed the preparation of substituted 2H-azirines. The reactions of 2-bromo-2H-azirine with methylamine led to the synthesis of alpha-diimines. 2-Halo- 2H-azirines were also established as building blocks for the synthesis of a range of heterocyclic compounds, namely, quinoxalines 10a-10d, 3-oxazoline, and 2H-[1,4]oxazines.32 Chemical reactions are described for the formation of aziridine-2-one and di-azirine-3-one derivatives as potential precursors for the original synthesis of amino-acids, proteins, pyrimidines, purines, nicotinamide and flavin.33
The N‟-2- (bromophenyl)-N,N-dimethylurea 16 underwent lithiation on the nitrogen to form a monolithio intermediate using MeLi, followed by bromine-lithium exchange using t-BuLi to give the dilithio species 17. 14 The intermediate 17 was then exposed to carbon monoxide to give 18, which after cyclization forms the intermediate 19, followed by loss of LiNMe2 to give 20, and finally after work up with dilute acid yielded the isatin product 1. 1 13 14 15 6 N O O 1) MeLi, 0 C CO Br N H O NMe2 2) t-BuLi, 0 C Li N O NMe2 Li C N Li O Li O NMe2 N O NMe2 O Li Li -LiNMe2 N H O O Li H3O + X X X X X X A rather versatile and novel two step synthesis of isatins was presented by Mironov in 2001 and allowed for the preparation of isatins containing electron withdrawing groups such as - CF3, -NO2, and -Cl. The method is based on the reaction between aromatic isocyanides and tertiary amines,15 where in the first step, 2-triethylammonio-3-arylaminoindolates 23 were obtained from the corresponding aromatic formamides 21 without isolation of the intermediate isocyanides 22. 16 Heating the 2-triethylammonio-3-arylaminoindolates 23 in excess thionyl chloride followed by hydrolysis led to the target
Metal chelating activity Briefly, 2 mM FeCl2 was added to different concentrations of test sample and reaction was initiated by the addition of 5 mM ferrozine. The mixture was vigorously shaken and left to stand at room temperature for 10 min. Absorbance was measured at 562 nm after 10 min.8 % Inhibition = [(AB - AA)/AB] x 100, where AB, absorption of blank sample, AA, absorption of test sample. 2.6. Antibacterial
Ethylene dichloride is a chlorinated organic compound consisting of two singly bonded carbon atoms bonded to one chlorine atom on each carbon and is assigned the CAS registry number 107-06-2scifinder. Ethylene dichloride should not be confused with 1,2-dichloroethylene which contains a double bond between the two carbons. Although a stable compound at room temperature, it does slowly decompose in the presence of oxygen and UV light turning a darker colour, and at temperatures above 340 oC it begins to decomposes forming vinyl chloride & HCL Ullmann’s & http://www.cdc.gov/niosh/npg/npgd0271.html . Table 1 lists the basic physical and chemical properties on ethylene dichloride. Table 1: Physical and Chemical Constantshttps://pubchem.ncbi.nlm.nih.gov/compound/11#section=Top Molecular Weight
Light yellow crystals; yield 87 %; mp. 118 ⁰C; 1H-NMR (CDCl3): δ 8.41 (m, 1H), 8.22 (m, 1H); 7.92 (m, 1H), 7.75 (m, 1H); 2.15(s, 3H); FT-IR: 3093, 2989, 1608, 1581, 1527, 1496, 1411, 1344, 1305, 1280, 1257, 1112, 1089, 1024, 987, 854, 750, 723 cm-1. 5-methyl-1-(4-fluorophenyl)-1H-tetrazole (2). White crystals; yield 87 %; mp. 82 ⁰C; 1H-NMR (CDCl3): δ 7.65 (dd, 2H), 7.39 (dd, 2H); 2.42(s, 3H); FT-IR (KBr): 3120, 2983, 1600, 1514, 1411, 1383, 1274, 1230, 1157, 1093, 1041, 989, 839, 690, 613 cm-1.
Ytterbium is a relatively reactive element that is usually stored in sealed containers to prevent its reacting with oxygen of the air. Ytterbium is one of the more common rare earth metals with an abundance in the Earth 's crust of about 2.7-8 parts per million. Its most common ore is monazite, which is found in beach sands in Brazil, India, and Florida. It is extracted from its ores by heating lanthanum metal with ytterbium oxide (Yb2O3): 2La + Yb2O3 2Yb + La2O3. Ytterbium was "discovered" over a period of more than 20 years by three chemists: Jean-Charles-Galissard de Marignac (1817-94) of France, Lars Fredrik Nilson (1840-99) of Sweden, and Georges Urbain (1872-1938) of France.