Pico Case Study Answers

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1. The PICO question in Muhlestein’s study. P: Men and women who are more than 50 years old and 55 years old respectively with at least three years history of DM or men and women who are more than 40 years old and 45 years old respectively with at least 5 years history of DM and who has used anti diabetic medication for at least one year. I: Coronary computed tomography angiography (CCTA)

C : Unscreened population.

O : Composite of all cause mortality, non-fatal MI ,hospitalization for unstable angina and Ischemic major adverse cardiovascular events (composite of CAD death, nonfatal MI, or Unstable angina). Q: In asymptomatic
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Stroke and carotid revascularization procedures were noted. # McEvoy’s study. In McEvoy’s study the follow up was scheduled at 90 days and 18 months in 2000 patients. Medication datas for statins, antihypertensives and oral hypoglycemic drugs were collected. Revascularizations, secondary test referrals and cardiac events like cardiac death, unstable angina requiring hospitalization and nonfatal myocardial infarction were documented at both 90 days and 18 months.

8. The summary measures or numbers from the study.
# Muhlestein’s study.
The primary and secondary end points was based on intention to treat and treated analysis during a mean follow up primary event of four years with (SD,1.7).Participants who have done CCTA screening the median follow up was 3.9 years with a range of 0.2-7.1. In the unscreened group the median follow up was 3.9 years with a range of

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