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Plumbago Zeylanica Case Study

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1. Introduction
Plumbago zeylanica L. belonging to the family Plumbaginaceae is an important plant of medicinal value. P. zeylanica is greatly valued in Ayurveda for treatment of cough, asthma and gastrointestinal disorders. In Sushrutha Samhitha it has been described as antiseptic, febrifuge, detoxicant, antihelminthic and considered valuable for curing migraine, jaundice, urinary calculi, internal abscesses, seminal weakness, vaginal discharges and insanity. In the Arabian Peninsula, it is mainly distributed over Oman, Yemen and the Southwestern region of Saudi Arabia. The use of the roots of P. zeylanica for treating skin problems has been recorded by early Muslim physicians. The hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities of P. zeylanica have already been reported (Kanchana and Sadiq, 2011; Thanigavelan et al., 2014; Sunil et al., 2012; Nguyen et al., 2004; Sudha and Sushma, 2009). Cisplatin (cis-diaminedichloroplatinum (II), CDDP) is an important anticancer drug used against the cancers affecting head, neck, lung, testis, ovary, and breast and it is well known that the main dose-limiting side effect of cisplatin is nephrotoxicity. Many medicinal plants have shown nephroprotective activity and may provide the basis for strategies following the adverse effects of heavy metals, antibiotics, analgesics, anti-cancer drugs and industrial agents. The present study aims to analyze the phytochemical features of the roots

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