Nervous System Dysfunction Research Paper

ABSTRACT
Objective: Nervous system dysfunction is a common and important complication in Primary Sjögren’s syndrome (pSS) and may be the cause of significant morbidity. A wide variety of peripheral (PNS) and central nervous system (CNS) complications are among the severe complications of pSS. Autonomic system involvements are also reported in pSS. In the present study we aimed to show the possible autonomic involvement in patients with pSS.
Materials and Methods: Peripheral nerve electrophysiological studies and the sympathetic skin responses (SSR) were studied in 29 patients with PSS (inactive disease period) and 31 normal controls.
Results: The latencies of SSRs were delayed and the amplitude of SSR decreased when compared with the control

It involves a recordable skin potential change following the application of an internal or external stimulus (14-16). Although it has been used in a variety of clinical settings to evaluate sudomotor sympathetic function, literature does not reveal any studies using SSR in pSS. Sympathetic cholinergic function may be studied by a non-invasive method-SSR which allows evaluation of the autonomic system in various

Autonomic symptoms can be seen in all forms of pSS-associated neuropathy. Abnormal pupillary responses (e.g. Adie’s pupil) and orthostatic hypotension were not only frequent in the sensory ataxic neuropathy group (12,17), but can also be seen in the small fiber sensory and trigeminal groups (12). The pathologic basis for pSS-associated autonomic neuropathy is unclear, but some cases appear to be due to an autonomic ganglionopathy (12); interestingly, Adie’s pupils are believed to be caused by ciliary