Essay On Proniosomes

Colloidal particulate carriers such as liposome or niosomes have been widely employed in drug delivery systems and producing them from proniosomes provides them a distinctive advantage. These carriers can act as drug reservoirs and the rate of drug release can be controlled by modification of their composition. These lipid vesicles can carry both hydrophilic drugs (by encapsulation) and hydrophobic drugs (in lipid domain). Due of their capability to carry a variety of drugs, these lipid vesicles have been extensively used in various drug delivery systems like drug targeting controlled release and permeation enhancement of drugs But there remains certain draw backs to be addressed and can be avoided if they are prepared in dry form. Proniosomes are dry formulation of water soluble carrier particles that are coated with surfactant. and hydrated by agitation in hot water to form niosomes provide an alternative with prospective for drug delivery via the transdermal route.

Proniosomes an Overview

Stability of dry Proniosomes is expected to be more stable than a premanufactured niosomal formulation. In release studies Proniosomes appear to be equivalent to conventional niosomes. Size distributions of Proniosomes derived niosomes are somewhat better that those of conventional niosomes so the release performance in more critical cases turns out to be superior Proniosomes are dry powder, which makes further processing and packaging possible. The powder form provides optimal flexibility, unit