Propofol Microemulsion Case Study

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8. RESULTS AND DISCUSSION 8.1 RESULTS The aim of this project was to prepare and evaluate the propofol Microemulsion. In this regard, Preformulation studies such as identification of drug by HPLC, compatibility between the drug and polymer, solubility of drug in various solvents were carried out by FT-IR. Results of the studies are presented in Table 8.1 Table 8.1: Identification and specifications of Propofol TEST SPECIFICATION RESULTS Appearance Colorless or very light yellow clear liquid Colorless clear liquid Solubility Very slightly soluble in water, miscible with hexane and methanol COMPLIES Identification By HPLC. The retention time of principal peak obtained in the solution chromatogram should correspond to that of principal peak obtained from standard solution COMPLIES…show more content…
The characteristic peaks of the Propofol were compared with the peaks obtained for physical mixture of Propofol and excipients. The characteristics peaks found in Propofol, physical mixture showed there is no chemical interaction between Propofol and Excipients and it could be concluded that the drug and excipients are compatible. 8.2.6 Optimization of Batch Formula Five trials (B-1, B-2, B-3, B-4, and B-5) were performed keeping drug and other excipients constant, only co-surfactants and their concentrations were varied. Out of the five trials B-3 was selected as it showed good particle size, zeta potential when compared to B-5 which showed higher particle size after 1 month stability studies. B-1 also showed good particle size and zeta potential but the percentage purity of that formulation was varied. 8.2.7 Optimization of Temperature Three trials (B-6, B-7 and B-8) were performed to study the effect of temperature in order to disperse the egg lecithin at a faster rate. Out of which B-6 was selected for further
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