Pseudomonas Aeruginosa Case Study

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ABSTRACT

Antibiotic resistance is a major global concern today. New resistance mechanisms of some bacteria such as Pseudomonas aeruginosa are emerging globally, threatening our ability to treat common infectious diseases. This research study focuses on determining whether the selected plant based anti-quorum sensing in conjuction with cipfloxacin, where pseudomonas aeruginosa is known to be resistant, will generate an effective results to aid the scare of antimicrobial resistance. The selected plants: Musa paradisiaca (AQS 01), Zingeber officinale (AQS 02) and Origanum vulgare (AQS 03) were certified at the Philippine National Herbarium for proper identification of genus and species and undergone ethanolic crude extraction & rotary evaporator at Industrial Technology Development Institute – Department of Science and Technology (ITDI-DOST) yielded a semi solid extracts of 3.9 % for AQS 01, 1.4 % for AQS 02 and 1.6% for
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This bacteria’s ability to develop resistances is due to mutation and due to the high chance of developing resistances, it often leads to serious infections. The researchers have mentioned that some strains and isolates of Pseudomonas aeruginosa have integrins that caused it to develop resistances to all reliable antibiotics due to the integrins possessing gene cassettes that encodes both carbapenemases and amikacin acetyltransferases.3
Pseudomonas aeruginosa can develop a virulence factor known as “biofilm”. Biofilm, as the researchers have mentioned, have several stages of development. First is reversible attachment, next is the irreversible attachment, third is first stage of maturation, then the second stage of maturation and finally dispersion. Biofilm cells have been observed to change motility, produce alginates and quorum sensing during the development of the

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