How ΔFosB Contributes to Addiction by Regulating The Expression of Specific Target Genes In Brain Reward Pathways.
Introduction
Neuroscience is vital in helping to understanding the importance of diseases among the brain, specifically drug addiction and how it is initiated. Addiction, also known as substance dependence [1], is a chronically relapsing disorder that is characterized by three major elements: (1) compulsion to seek and take a drug, (2) loss of control in limiting intake, and (3) emergence of a negative emotional state (e.g., dysphoria anxiety, irritability) when access to the drug is prevented (defined here as dependence) [19].
Neuroscience correlates the relationship between brain function and behavior, making it particularly
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A majority of the theories surrounding drug tolerance and dependence emphasize the physiological outcome, or repeated pharmacological stimulation. Theories of addiction can be thought of as moral theories, disease theories, learning and behavioral theories, or sociocultural theories. From a moralist standpoint of addiction the moral results of weakness are associated with character traits such as: pride, resentment, or laziness. Addiction is a symptom of an underling problem; therefore, individuals can not simple recover through the use of willpower and discipline. One must address the underlying issue or else relapse could occur. Next, the disease theory states, an individuals addiction is causes by a physiological deficit which makes an individual unable to tolerate the drug. For example, certain individuals are more susceptible to cocaine than others, depending on the individual’s bodies responsiveness to the drug. One may be more easily addicted if their body produces a more reinforcing or rewarding response when a particular drug is taken. In addition, the learning and behavioral theory suggest addiction is learned both through observation and vicarious reinforcement of direct experience. In other words, individuals learn through observation that addictive behaviors can be used to escape from pain, cope with stress, or even deal with depression. Those who find relied on a pleasurable behavior are more likely to engage in that behavior more often. Lastly, the sociocultural theories expands upon the learning theory. Initiation of addictive behaviors are supported by influences form ones surrounding environment, such as social circles (peer pressure), or
For starters, Hari discusses how society over the years has made misconceptions about addiction, because of this addicts have been wrongfully treated, and blame was placed incorrectly. The author goes on to explain two different stories; both being well known about the prescription drug crisis. One being the fact that even the most powerful drugs such as diamorphine hasn’t caused addiction (Hari). In fact, that didn’t make sense to Hari on how powerful drugs were used in extreme medical cases and through prolonged use none became addicted. This is one of the misconceptions about addiction.
Besides, addiction is a treatable disease and he also states his idea about how to solve it. Therefore both of the authors express the worry to drug problem in
Connecting the brain and addiction has helped find effective treatments for these patients. However, studies are still being done on addicts and the brain’s response to addiction. According to Filbey, “Future work can expand on this knowledge by determining individual differences, such as genetic and environmental factors, that influence the addiction connectome” (Filbey, 2013, p.
The biological explanation of the brain in regards to drug addiction is interesting. According to the textbook, "Studies have found convincing evidence that drugs such as alcohol, heroin, and cocaine act directly on the brain mechanisms that are responsible for reward and punishment. " When one use drugs, the drug stimulates the areas of the brain that create the sensation of pleasure and suppress the pleasure of pain, as, a result, the user receives reinforcement to engage in further drug-taking behavior. The psychological explanation of drug abuse, "Focus on either personality disorders or the effects of social learning and reinforcement on drug-taking behaviors."
Have you ever been stressed out to the point where you just want to detach yourself from reality? Many reasons can contribute to this such as school, work, or your home life. All of those can contribute to a build up in stress levels and cause you to want to just get away any way you can. Drinking alcohol, taking drugs and/or self-harm are some of the many ways people will try to escape from reality. People should not use drugs or alcohol to try to escape from reality.
In brief, Chapter 7 is about various types of addictions, drugs (illicit and licit), and treatments for certain addictions. The signs of addiction can be hard to spot if you are an enabler of the addicted, or the addicted person, but the signs are there nonetheless. The signs one should watch for are compulsion (otherwise known as obsession), loss of control, negative consequences (whether physical, with the law, or mental), and denial in the addiction from the addict himself. There are various types of addictions that will manifest the 4 signs of addiction. These classifications of addictions include an addiction for gambling, eating, exercise, shopping (or compulsive shopping), drugs, and the internet (technology).
Addiction is a disorder of the brain where a person feels he has to take the drug despite its destructive effects (Volkow, Koob and McLellan). Dependence is a state normally associated when an
I noticed cocaine is the drug of choice to almost all of the Prop-36 probationers. Many of the addicts would share that, after the use of such drug, they would hallucinate and want more after they came off of the drug. This study explains how the abnormality of dopamine in certain areas of the brain are associated in how cocaine takes full control of your will and can lead to drug addiction. A perfect example is that of a female being assessed stated that she felt horrible after the first use and the second use. Eventually she became addicted, but not because she liked it, it was because she was forced to use it in order to survive in the streets.
Journal Of Food & Drug Analysis, 21s73. Genes and Addiction. (n.d.). Retrieved May 15, 2016. Gowing, L. R., Ali, R. L., Allsop, S., Marsden, J., Turf, E. E., West, R., and Witton, J. (2015), Global statistics on addictive behaviours: 2014 status report.
The three main theories that are most relevant to substance abuse are functionalism, social-conflict, and symbolic-interactionism which only focus on micro
It is a universally held beleif that addiction ruins lives. Affecting the young and old, male and female, and people from different ethnicities, cultures, and social brackets, addiction is widely regarded as a societal illness with no easy solution. A particularily damaging assumption is that a drug or sex addict, for instance, is the root cause of their own suffering. This can potentially lead to a chain reaction where the guilt placed upon a human being strengthens the desire to escape from said guilt. This is particularily damaging to a teenager, to whom an external stimuli is no longer required after a few years of guilt inflicted by their parents.
When a person falls in love or gets addicted to drugs, their bodies behave in the same way. The warm and cozy feeling of being in love floods the brain with chemicals and hormones that produce feelings of pleasure, obsession and attachment. In Romeo and Juliet, Juliet did not just fall in love with Romeo. Lovers also feel a rush of exhilaration when thinking about him or her; it is a form of “intoxication.” Both love and addiction engage the same regions of the brain, the “rewards system.”
Literature Review Substance Use Disorder Defined According to the American Psychological Association, the definitional boundaries of what addiction is has changed multiple times over the years. Addiction was relabeled dependence in 1964 by the World Health Organization, as it thought that the word addiction closely linked to opiate use. A few years ago, the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) was released and combined the diagnostic categories for substance abuse and substance dependence (American Psychiatric Association, 2013). These diagnoses have replaced the term with substance use disorders.
Drug abuse is caused by psychological, genetic as well as environmental factors and can have significant damaging effects on health. Psychological factors are associated with the development of drug abuse. Drug abuse often occurs
All these characteristics led to the conclusion that drug addiction is a chronic, relapsing brain disease that is characterized by compulsive drug seeking and use. It is considered as a brain disease because drugs change the structure of the brain, and how it works. Every drug affects different systems of the brain. For example, in the case of cocaine, as the brain is adapted in the presence of the specific drug, brain regions responsible for judgment, decision-making, learning, and memory begin to physically change, making certain behaviors “hard-wired.” In some brain regions, connections between neurons are pruned back.