Qnt 531 Week 3 Review Paper
Criteria for considering studies for this review We included any type of study design with data collection. There was no age restriction and we included studies looking at patients presenting with fever who were subsequently tested for dengue using both the Tourniquet test and Enzyme-Linked Immunosorbent Assay (ELISA). For this review: Dengue fever was considered: “Fever along with at least 2 of the following: headache, retroorbital pain, muscle pain, joint pain and rash. May be accompanied by bleeding complications such as epistaxis, gingival bleeding, gastrointestinal bleeding, hematuria)”; whilst Dengue hemorrhagic fever was considered as: “Dengue fever with haemorrhagic manifestations such as petechiae and mucosal or gastro-intestinal …show more content…
We separated potential studies for full-text reading. A third review author (ET) resolved any disagreements. We described the reasons for including and excluding trials.
Data Extraction and Quality Assessment
Two review authors (AJG, HR) independently extracted data from the included studies using a standard data extraction form. In this form we extracted information of study design, participant description, index test description, reference test description, dengue classification and total number of participants. A 2x2 table was created for each study comparing both tests.
All included studies were assessed for their methodological quality using the quality assessment tool for diagnostic accuracy studies (QUADAS II). The tool is composed of 17 items regarding study patient selection, index test, reference standard and flow and timing. For each domain mentioned there are items for risk of bias and applicability. Items were scored as positive (low risk of bias), negative (high risk of bias), or insufficient information (unclear). A description of each assessment was described in the results section.
Data Synthesis and Statistical
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