Insulin Preparation Research Paper

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Insulin is a kind of hormone that is produced by human pancreatic beta cell. The primary role of this hormone is to control the glucose level in blood. There are many different types of insulin preparation available in market. Insulin preparation can be classified into 5 major groups namely, rapid acting, short acting , intermediate acting, long acting and pre-mixed insulin preparation as well. They are grouped according to how rapid are these medications work and how long their effect can last for.
The examples of rapid acting insulin preparation include Insulin Aspart, Insulin Lispro as well as Insulin Glulisine. The first rapid acting insulin preparation will be discussed is Insulin Aspart. Novolog is the trade name of insulin Aspart. NovoLog …show more content…

NPH is crystalline insulin zinc suspensions which combine with protamine at neutral ph. This combination will result in formation of less soluble complex. As a result, absorption of insulin will be delayed. NPH will starts to work within 2 hours after administration and it will reach the peaks intensity in plasma at around 8 to 12 hours after injection. NPH insulin can last for about 12 to 24 hours. Humalin N, Novolin N are the examples of NPH. This type of insulin can be administered only by subcutaneous route. It cannot be given intravenously, due to this reasons, NPH cannot used to treat emergency hyperglycemia which require intravenous administration. Once or twice dose of NPH can be given to patients with type 1 or type 2 diabetes mellitus. Before the administration of NPH, it must be roll vigorously so as to mix the insulin together with …show more content…

These types of insulin are combined in order to provide a biphasic effect with speedy onset and extended duration of action. The most typical pre-mixed insulin preparations used are combination of regular insulin with NPH. The proportion in percent of NPH: regular are available as 75:25 (Humalog Mix 75/25) 70:30 (Humulin 70/30, Novolin 70/30) and 50:50 (Humalog 50/50). Pre-mixed insulin should be administered 10 to 30 minutes before meals and two doses per day should be given. Different combinations of pre-mixed insulins have different peak intensity. Most of them can last for at least 10 to 16

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