Drug Delivery System Essay

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FORMULATION, CHARACTERIZATION AND EVALUATION OF SELF-EMULSIFYING DRUG DELIVERY SYSTEM OF ROSUVASTATIN CALCIUM NIRAV KHANT*, MEENAKSHI PATEL, MANALI PARIKH Babaria Institute of Pharmacy, Varnama, Vadodara. Address: Babaria Institute of Pharmacy, Varnama, Vadodara-391240 E-mail: nirav_khant@yahoo.in ABSTRACT The objective of this work was to develop Solid self-emulsifying drug delivery system (Solid SEDDS) for increasing the bioavailability of poorly water soluble drug Rosuvastatin Calcium. Selection of formulation components was done on the basis of their drug solubilisation capacity. Pseudo ternary phase diagrams were constructed to identify the efficient self-emulsification region. Liquid SEDDS were prepared and optimized …show more content…

Different oils like Isopropyl Myristate (IPM), Isopropyl Palmitate (IPP),Oleic acid, Peceol, Soyabean oil, Jojoba oil, Olive oil, Castor oil and Propylene glycol were taken for solubility studies. A known amount of excess drug was added to 2 mL of each of the selected vehicle. It was mixed in Cyclon mixer and kept at 25°C for 48 hr. After reaching equilibrium, each vial was centrifuged at 5000 rpm for 10 min and excess insoluble drug was separated by filtration using Whatman filter paper. Solubilized drug concentration was quantified by UV spectroscopy and Insoluble drug was weighed to check the mass balance. [4,5,6] Selection of surfactant and co-surfactant: The criteria for the selection of surfactant are its HLB value, drug solubility and non-toxic nature. Several surfactants like Tween-20, Tween-80, Transcutol, PEG 400 and Cremophor EL were screened by above mentioned method. Cosurfactants were selected based on their ability to form stable and clear microemulsion at a minimum concentration. Based on this, several cosurfactants like Polyethylene Glycol 400 (PEG 400), Glycerol, Polyethylene Glycol 600 (PEG 600), Isopropyl alcohol and Isobutyl alcohol were screened. [4,5] Compatibility of Drug with Other …show more content…

Hence, Tween 20 was selected as Surfactant for enhancing drug loading capacity. Co-surfactants were selected based on their ability to form stable and clear microemulsion at a minimum concentration. Based on this, several co-surfactants like Polyethylene Glycol 400 (PEG 400), Glycerol, Polyethylene Glycol 600 (PEG 600), Isopropyl alcohol and Isobutyl alcohol were screened. From that, PEG 400 was selected as gave transparent and clear microemulsion at low concentration. Solubility of drug in PEG 400 was checked and it was found to be 3.23 mg/ml. Compatibility study of drug with selected excipients: a) Drug + Peceol Figure 3 FTIR Spectra of Drug with Peceol b) Drug + Tween 20 Figure 4 FTIR Spectra of Drug with Tween 20 c) Drug + PEG 400 Figure 5 FTIR Spectra of Drug with PEG 400 Table 5 Interpretation of IR Spectra Functional groups IR frequency reported (cm-1 ) Observed value (cm-1 ) Drug + Peceol Drug + Tween 20 Drug + PEG 400 C-F 564 568.94 721 574 575 Para-substituted Benzene 844 844.37 721 849 842 C-N (stretch) 965 964.09 928 946

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