Rotaxane is a mechanically interlocked chemical architecture consisting of a dumbbell shaped molecule which passes through a macrocycle. After it was first introduced in 1980, many researchers in supramolecular chemistry had utilized its unique property to develop diverse chemical sensors for metal ions, anions and even explosives by incorporating different functional groups to the basic rotaxane architecture. However, only few of rotaxane-based sensors have been applied to medical uses. In this project, an anthracene containing dynamic [2] rotaxane is prepared through self-assembly according to Wong, W. et al., and studied for metal ions sensing properties using fluorescence spectrometry. Two metal salts, Fe(ClO4)2 and Fe(ClO4)3 were chosen …show more content…
Lehn had prepared cryptands and made great contributions to the field and paved the way for much up-to-date advancement. By then, I.T. Harrison and S. Harrison first reported that they had synthesized a “stable complex which consisted of a macrocycle and a threaded chain”,12 which was known as the world’s first rotaxane. Synthesis Methods With the advancement of supramolecular chemistry, such as knowing the concept of self-assembly, template effect and so on, Stoddart was able to let the molecules assemble themselves, which forms the basis of common rotaxane synthesis today. Nowadays, there are numerous methods to synthesize rotaxanes. In general, there are 4 common approaches, namely capping, clipping, slipping and active template method. Each of them will be briefly introduced as follow. Capping method, which is also known as “stoppering”, requires the preparation of a pseudorotaxane precursor, which comprises of a linear moleculae threaded through a macrocyclic one. Then both ends are capped by 2 sufficiently large groups to form a [2] rotaxane.2 Figure 4. Schematic representation of the capping method For clipping method, a bumbbell-shaped molecule and an acyclic precursor is prepared, then the remaining part of the macrocycle is assembled to the precursor and finally forms a [2] …show more content…
Synthesis of the Squaraine-RotaxaneAdopted from: Arunkumar, E. et al. Chemistry - A European Journal 2006, 12 The squaraine rotaxane allow the visualization of biological process such as bacterial cell division, which allows the generation of real-time fluorescent movie.3-4 Principles and MethodologiesThe following principles are discussed briefly one by one to aid the more comprehensive understanding of the whole project. They include examples of rotaxane sensors, the property of the anthracence-containing [2] rotaxane, the proposed metal ion sensing mechanism and the principle of fluorescence and fluorescence spectroscopy. Rotaxane Sensors The highly flexible rotaxane architecture gives rise to a wide variety of rotaxane sensors. By integrating different functional groups, researchers are able to develop rotaxane sensors for metal ions, anions and even explosives. For example, in 2007, Chen et al. developed a [2] rotaxane which contains a 2,2’-bipyridinium (BP-H2) ion and crown ether like macrocycle which is responsible for the sensing of 5 physiologically metal ions, including Li+, Na+, K+, Mg2+ and
All the fundamental vibrations are IR active stable structure. The harmonic vibrational frequencies calculated for doped fullerene with glycine have been compared from low frequency (below 1000 cm-1) to high vibrational frequency (above 1000cm-1) as shown in Table5. The symmetrical stretching vibrations of NH2 group are assigned in 3079, 3569 and 3613cm-1. The two strong stretching vibrations are found at 3569, 3695cm-1 for doped fullerene C19Si-glycine and 3569, 3715cm-1 for C19Ge-glycine. The strongest carbonyl stretching, vibration peak at 1769cm-1for doped fullerene interacting with amino acid C19Si-glycine and at 1780cm-1 for doped fullerene C19Ge-glycine peak are presented in Fig 7.
Write 9-4x^2-x+2x^4 in standard form You first look at all the the numbers in the polynomial and see which coefficient has the highest number exponent. (the degree) which is 2x^4. Then you keeping descending down so -4x^2 would be next. Then you look at the numbers and variables in the problem, all you have left is 9 and -x you always put the variable first so it would be -x, then 9. So your answer would be
Magnesium is added to a capped and dried flask with a crystal of iodine, ether and a drop of 1,2-dibromoethane. The iodine was essential to activate the magnesium. Ether was used as the solvent because there are no acidic hydrogen’s on ether that can potentially react with the Grignard reagent and also because ether has two lone pairs on the oxygen that can help to stabilize the magnesium
Nucleophilic Substitution: Preparation of 1-Bromobutane and Alkyl Halide Classification Tests Introduction This procedure was undertaken in order to convert a primary alcohol, 1-butanol, into a primary alkyl halide, 1-bromobutane. This was done using hydrobromic acid. Additionally, tests were performed to assess the degree of the alkyl halide: primary, secondary or tertiary.
World renowned bartender, Dil Howlter, was created on September 24th, 2012, to the age of 18. His parents, Dan and Phil, proudly gazed upon their 18 year old bundle of joy when the first brought him to their new house in the town of Willow Creek. There, Dil would spend the rest of her life, obeying every wish that his fathers asked of him.
“Rikki-tikki-tavi” Retelling The events that brought Rikki to his new home was that a high summer flood washed him out of his burrow. During the flood he was kicking, and clucking and got drained in a ditch on the side of the road. He then saw a little patch of grass floating and clung on to that but he lost his senses.
Over the years of 1933-1945 over a million people were killed due to the Holocaust and more than half of them were Jewish. January 20, 1942 there was a meeting called the Wannsee Conference held by Nazi officials and attended by government ministers to discuss the problem of the European Jews. Reinhard Heydrich, chief of the Reich Main Security Office was in charge of the meeting. Before this meeting there had been major events that occurred all over Europe causing the Jewish race to become belittled in most of Europe. Adolf Hitler preached that the Jews were not the same as them and Germany needed to remove them from their country and the surrounds areas.
5. Public trials and executions serve as a deterance of deviant behaviors. These sanctions act as a way to set an example and for people to see what will happen to them if they do the same thing, These sanctions can also be seen as reinforcing boundaries. Although public executions and trials in “town square” are not as common in most countries today, the media is utilized to fulfil the same purpose. When there are high profile cases going on in the United States often tmes the full trial and sentancings are televised so that much of society can see what the repercussions are for defying a social norm.
Warhawk Academy is a greatly recognized student organization for anyone to join because of the many benefits it obtains. Warhawk Academy is uniquely designed for students that want to be a part and give back to their school by participating in many scholastic activities. Warhawk Academy is a selectively-based organization; therefore, admission into this organization is rigorous. This particular organization is socially and scholastically beneficial, and is prosperous for many of its members through the acceptance into the organization and the skills that are gained by being a member. Warhawk Academy is an organization that is designed to enhance the student’s performance in school and in society.
TESTIMONY IN FAVOR OF HOUSE 3384 AN ACT REQUIRING PHYSICIAN TRAINING ON ALZHEIMERS AND DEMENTIA PUBLIC HEALTH COMMITTEE FEBRUARY 24TH 2016 Good afternoon, my name is Olivia Guiney, I am here as a concerned healthcare provider, representing the Alzheimer’s Association, Massachusetts/New Hampshire chapter. I wish to express full support for the bill H. 3384, “An Act Requiring physician training on Alzheimer’s and Dementia.”
The goal of the experiment is to synthesize a bromohexane compound from 1-hexene and HBr(aq) under reflux conditions and use the silver nitrate and sodium iodide tests to determine if the product is a primary or secondary hydrocarbon. The heterogeneous reaction mixture contains 1-hexene, 48% HBr(aq), and tetrabutylammonium bromide and was heated to under reflux conditions. Heating under reflux means that the reaction mixture is heated at its boiling point so that the reaction can proceed at a faster rate. The attached reflux condenser allows volatile substances to return to the reaction flask so that no material is lost. Since alkenes are immiscible with concentrated HBr, tetrabutylammonium bromide is used as a phase-transfer catalyst.
The mobile phase used was a mixture of ammonium acetate buffer and acetonitrile at a ratio of 400:600. A flow rate of 1 mL/min was maintained, and the detection wavelength was 292 nm (22). The required studies were carried out to estimate the precision and accuracy of the HPLC method and were found to be within limits [percent coefficient of variation was less than 15%]. Sample preparation briefly involved 0.4 μ membrane filter through which the sample was filtered, diluted with mobile phase, and 10 μL was spiked into
Benzyne Formation and the Diels-Alder Reaction Preparation of 1,2,3,4 Tetraphenylnaphthalene Aubree Edwards Purpose: 1,2,3,4-tetraphenylnaphthalene is prepared by first producing benzyne via the unstable diazonium salt. Then tetraphenylcyclopentadienone and benzyne undergo a diels-alder reaction to create 1,2,3,4-tetraphenylnaphthalene. Reactions: Procedure: The reaction mixture was created. Tetraphenylcyclopentadienone (0.1197g, 0.3113 mmol) a black solid powder, anthranilic acid ( 0.0482g, 0.3516 mmol) a yellowish sand, and 1,2-dimethoxyethane (1.2 ml) was added to a 5-ml conical vial.
Lecturer Date Introduction Theoretical Background Procedure The procedure was segmented into two categories, the reaction set up and the crude product isolation. Reaction set up The magnetic stirrer was prepared through placing it in the fume cupboard. 1 mmol of L-Phenylalanine was placed and weighed in a 5 mL conical vial.
Next, the oxygen is protonated from the 3-nitrobenzaldehyde, which is then followed by an elimination reaction where this acts as a leaving group. The product is the trans-alkene present in the product. After the reaction was completed, purification of the product was conducted using semi-microscale recrystallization.