Secobarbital Research Paper

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Seconal Sodium (Secobarbital Sodium)
Classification: Barbiturates (Broad)
Molecular Weight: 260.27 g/mol pKa: 7.8
Molecular Formula: C12H17N2NaO3
IUPAC Name:
5-pentan-2-yl-5-prop-2-enyl-1, 3-diazinane-2, 4,6-trione Description
Secobarbital is a barbiturate, which is a nonselective CNS depressant, they are often used as sedatives. Secobarbital was at one point used for induction of anesthesia before other general anesthetics agents became commonly used. The drug has also been prescribed for short-term treatment of insomnia on rare occasions. Secobarbital is a CII schedule drug, substances in this schedule have an elevated potential to be abused.
Secobarbital is orally administered, 100 mg as a sedative and 200 to 300mg 1 to 2 hours
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If the drug is administered in a rectal pathway approximately 100% of Secobarbital is absorbed. The absorption of Secobarbital is rapid and takes duration of 3-4hrs.
Since Secobarbital has extremely high lipid solubility and protein binding the drug is distributed to tissues and fluids across the body. The volume of distribution of Secobarbital in adults is 1.5 L/kg
Secobarbital is metabolized by the liver via the major metabolite penultimate oxidation of the 1-methylbutyl substituent to form 5-allyl-5(3 '-hydroxy-1 '-methylbutyl)barbituric acid (hydroxysecobarbital).
The elimination half-life of Secobarbital in children is 2.7 to 13.5 hours. Secobarbital is found to have an elimination half-life of approximately 30 hours in adults. The drug has also been found to have a plasma half-life of 15 to 40 hours (mean 28 hours) in adults.
Toxicity
The drug is known to cause adverse reactions such as somnolence, agitation, hypoventilation, bradycardia, and headaches. Taking Secobarbital with alcohol or other CNS depressants has been shown to have the ability to increase the danger of complex behaviors and have the negative effect of producing additive CNS-depressant

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