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Sliding Filament Theory Of Myosin

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The AP travels along the sarcolemma and into the T-tubules where voltage sensors called Dihydropryridine (DHP) receptors cause Ca2+ to be released from the sarcoplasmic reticulum into the muscle cell cytoplasm. Sliding filament theory describes how myosin interacts with actin to contract the sarcomere. Ca2+ binds to the troponin of the thin actin filament, shifting the tropomyosin off of the myosin-binding sites. The myosin head then binds the actin and forms a cross-bridge. The myosin is also bound to ADP. Once the cross-bridge is formed, the ADP is released, triggering a power stroke, in which the myosin pulls on the actin, and the two filaments slide across each other, shortening the sarcomere. ATP binds the myosin head and the myosin dissociates

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