Lipid Lipids Research Paper

SOLID LIPID NANOPARTICLES (SLNs):
SLN’S are recent advances to vesicular drug delivery systems. It consist of solid lipid core surrounded by a phospholipid layer. The lipid used should be biocompatible and exist in solid state at room temperature and body temperature.
Slns are not easily phagocytised by reticulo endothelial system and hence remain in the systemic circulation for longer time period. Slns can be linked to specific ligands which will recognise receptors present on specific cells and hence achieve targeted drug delivery thus enhancing bioavailability of the drug. Sln can be used to incorporate both hydrophilic as well as hydrophobic drugs.
COMPONENTS:
1.Lipids:
Triacyl glycerols: Tricaprin, Trilaurin
Acyl glycerols: Glycerol monostearate, Glycerol behenate, Glycerol palmitostearate. Waxes: Cetyl palmitate.
Hard fats: Witepsol H, Witepsol W.
2. Surfactants:
Soya lecithin, egg lecithin,

Thus this formulation improved oral bioavailability by directly entering systemic circulation thereby reducing hepatic metabolism.

Anil .B. Jindal et al prepared asymmetric lipomer using Gantrez AN 119 as the polymer and glyceryl monostearate as the lipid composition21. Due to its size and lipid composition lipomer can enter into the lymphatic circulation and treat many splenic diseases as well as cancers and enhance the delivery of si- rna molecules which otherwise becomes difficult to target at the site of action.

LIPOSOMES:
Liposomes are most widely used colloidal vesicular systems having many applications in the field of medicine. Liposomes can deliver the drug through oral, ocular, parentral and topical route.
Liposomes consist of a phospholipid bilayer surrounding the aqueous core. It can load hydrophilic as well as lipophilic drug due to its amphiphilic