As mentioned in number 13, the data for the melting point makes sense because my pure product and given compound almost perfectly matched. 17. Again as explained in number 14, the TLC data made sense because my pure compound and 4-tert-butylbenzyl phenol had similar distances from the solvent origin of the plate. The presence of benzyl bromide and benzyl alcohol also explains how not all the product dissolved in the filtrate. The possible explanations and changes to make are similar to the previous questions.
10 ml NaOH was again added and mixed for 15 seconds to make lump free slurry. The mixture was stirred and allowed to stand for 3 minutes. An additional 10 ml of caustic soda was poured in the beaker and stirred for 10 minutes to mix thoroughly. In between the stirring, remaining 30 ml of 17.5% caustic soda was added at 2.5, 5 and 7.5 minutes in installments of 10 ml each. This mixture was allowed to remain in the beaker for 30 minutes further, making the total treatment time of 45 minutes from the beginning.
The resulting hexahydropyrimidines(b) need not to be isolated and can be converted directly into DHPMs. This method works particularly well for aliphatic aldehydes and thiourea and produces high overall yields of the desired compound.21 Scheme-4: There are several combinatorial approaches towards DHPMs have been advanced using solid phase. In the solid-phase modifications of the Biginelli condensation, the urea component is linked to the solid support via the amide nitrogen, which invariably leads to the formation of N1-functionalized
Lab Report 10: Nitration of Bromobenzene Raekwon Filmore CM 244 Section 40 March 27, 2018 Introduction: For this experiment, nitration of bromobenzene was the focus of the lab. The benzene is an aromatic compound and when it reacts with wither a mixture of sulfuric acid or nitric acid creates what is known as a nitro group. The formation of the nitro group is possible because it is an electrophilic aromatic substitution reaction. The creation of the nitronium ion is shown below: The reaction with the nitronium ion with bromobenzene creates three products instead of one. Depending on where the nitronium group or the alpha complexes of the reaction is on the ring, determines whether the product will be meta, para or ortho.
Degradation study of Product 01 using Aqueous 1N NaOH solution .The mechanism is operated by hydrolysis. The hydroxyl group (-OH) of NaOH attacks an electrophilic carbon of >C=O group which an removal of tertiary Nitrogen gives 4-MBA and PD as by products. Degradation study of Product 02 using Aqueous 1N NaOH solution . The mechanism is operated by hydrolysis. The hydroxyl group (-OH) of NaOH attacks an electrophilic carbon of >N-C=O which as rearrangement gives carbonial .
The goal of the experiment is to synthesize a bromohexane compound from 1-hexene and HBr(aq) under reflux conditions and use the silver nitrate and sodium iodide tests to determine if the product is a primary or secondary hydrocarbon. The heterogeneous reaction mixture contains 1-hexene, 48% HBr(aq), and tetrabutylammonium bromide and was heated to under reflux conditions. Heating under reflux means that the reaction mixture is heated at its boiling point so that the reaction can proceed at a faster rate. The attached reflux condenser allows volatile substances to return to the reaction flask so that no material is lost. Since alkenes are immiscible with concentrated HBr, tetrabutylammonium bromide is used as a phase-transfer catalyst.
They have a relatively high level of hydrophilicity. Conversely, cationic surfactants such as cetyltrimethyl ammonium bromide (CTAB) release a positive charge in an aqueous solution. On the other hand, in alkali pH, amphoteric surfactants act as anionic while in acid pH, it act as cationic. Non-ionic surfactants such as partially hydrolyzed PVA (polyvinyl alcohol) have no charge (Li et al, 2008). Among four types of surfactants, partially hydrolyzed PVA is most frequent used because it gives the smallest microsheres (Jeffrey et al, 1991).
Introduction Grignard reagent is considered as an organometallic compound or it's the composition of electrophilic and nucleophilic that electrophilic is the carbon atom of organic halide which is directly attached to the halogen, it's reactivity can be switched to the nucleophilic reactivity by conversion an organomagnesium halide. It has the general formula of (RMgX) and it has a general nomenclature which it's called magnesium alkyl halide. We can get Grignard reagent by adding one of solutions of alkyl halide to an ether, slowly. Then, garbling them that's leads to the boiling of solution and magnesium becomes disappeared so, we can get the reagent. Grignard reagent is also considered as the best known reagent of all organometallic compounds, as carbon atom is connected to a metal atom which may be
During this step, I observed that there were bubbles in the solution, especially at the bottom of the beaker. After adding the HLC, there solution had a slight yellow tint. Next, I mixed 0.529g of sodium acetate in 3mL of water and added 0.679g of acetic anhydride to the aniline solution and immediately added sodium acetate. The solution was cooled in an ice bath for fifteen minutes. During this time, I noticed the formation
The objective of this experiment was to use an aldol condensation reaction to synthesize 3-nitrochalcone from 3- nitrobenzaldehyde. This was accomplished with a Diels-Alder reaction that utilized 3-nitrobenzaldehyde, acetophenone, ethanol, and sodium hydroxide. The mechanism for the synthesis of 3-nitrochalcone is presented in Figures 1 and 2. The alpha carbon on the acetophenone is deprotonated. This is followed by the attack of the alpha carbon anion on the carbonyl carbon on the 3-nitrobenzaldehyde.
When determining the solubility of malonic acid in different solvents both water and methyl alcohol were found to be polar when mixed with malonic acid. Hexane however was insoluble. Lastly biphenyl was mixed with water and was found to be insoluble, methyl alcohol was determined to be partially soluble.Hexane on the other hand was the only soluble solvent for biphenyl 2. Part B. of this experiment determined the solubility of different alcohols in hexane or water. Alcohols 1-Octanol, and 1-butanol were both found to be soluble in hexane while methyl alcohol was determined to be insoluble.
The goal of this experiment was to synthesize the unknown ester through Fischer Esterification. This procedure involves treating a carboxylic acid with an alcohol and a strong acid catalyst. This procedure was also catalyzed with heat at 160oC-180oC, to keep the temperature from exceeding the boiling points of the compounds in use. The acid catalyst protonated the double bonded oxygen atom to force the atom to pull two electrons away from the double bond in order to stabilize the atom’s charge. As this electron shift occurred, the alcohol attacked the carbocation that lost its double bond.
The silver ion TLC was prepared through the following procedure: Silver nitrate was dissolved in 10 ml of distilled water. This aqueous solution of silver nitrate was absolutely mixed with 9 g of silica gel (10 ~ 40 μm particles). Then, a 10 × 5 cm TLC plate was coated with the above slurry and activated for 1 h at 90 °C before use. They were immediately transferred into a desiccator in dark for storage after cooling. 32 100 μL of afore-prepared sample solution and the mixed reference standard were diluted 100 times with ethyl acetate.