Sodiumbisulphate Lab Report
ABSTRACT
A variety of acetamido ketones and ketoesters are readily prepared in high yields under extremelymild conditions via a three component coupling of aromatic aldehydes, enolizable ketones or ketoesters and nitriles in the presence of 10 mol % of sodiumbisulphate and a stoichiometric amount of acetyl chloride. A solution of 10 mol % of sodium bisulphate in acetonitrile provides a convenient reaction medium to carry out athree component reaction under mild conditions with high yield .Synthesized compounds are studied for their microbial activity.
Keywords: Acetamido carbonyl compounds; aromatic aldehydes; enolizable ketones; sodiumbisulphate
INTRODUCTION
Multi-component reactions (MCRs) have emerged as one of the most useful synthetic
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UJP 2014, 02 (06): Page 85-88 www.ujponline.com
acetonitrile in the presence of Magnesium Sulphatecatalyst (Scheme 1). Supported Co(OAc)2 and p-TSA. Although, a large number of methods are reported for this transformation, some of them lack the generality in producing beta amido ketone as they are restricted to acetonitrile giving the corresponding beta acetamido ketones. Furthermore, many of these methods require either a long reaction time or harsh reaction conditions or the reaction has to be carried out under an inert atmosphere or the use of expensive catalyst. Therefore, the development of simple, efficient and general methodology for this three-component reaction is still desirables a result, several strategies have been developed for the preparation of beta -acetamido
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The progress of the reaction was followed by TLC. After completion of the reaction, sodium bisulphate was isolated and could be reused (after the evaporation of water and solvent). Then the mixture was cooled and poured into 100 mL of ice-water. The solid residue was separated and dissolved in dichloromethane. The organic phase was absorbed on silica gel and purified by column chromatography petroleum ether (60-80 ºC) / ethyl acetate (9/1). All the products were identified by comparison of their 1H NMR and IR data with those of authentic samples. The spectral data of representative β-acetamido ketones are given
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