Chemical Photosynthesis Lab Report
GREEN SOLVENTS IN CHEMICAL SYNTHESIS
1. INTRODUCTION
Solvents act as a liquid medium for the reaction to take place. They are also used after synthesis for extraction, purification and drying. Thus, they are of key importance in chemical industries. Solvents also play important role in chemical analytical methodologies, spectrometry and measurements of physicochemical properties. Aromatic solvents (benzene, toluene, etc), chlorinated and polychlorinated solvents (carbon tetrachloride, chloroform, dichloromethane, etc) and other organic solvents (DMSO, DMF, petroleum ether, diethyl ether, acetone, etc) are used in great quantities in many laboratory and analytical techniques. Majority of the solvents used in chemical synthesis are organic solvents
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Herein, a mixture of (E)-1-(1-benzyl-5-methyl-1H-1, 2, 3-triazol-4-yl)-3-phenylprop-2-en-1-one, 2a, guanidine hydrochloride and NaOH in water or ethanol was refluxed for 30–40 min. The reaction mixture was then neutralized using dil. HCl after pouring on excess crushed ice. The precipitated 1, 2, 3-triazolyl-2-aminopyrimidine 3a was then filtered and recrystallized from ethanol. 82% of yield was obtained using water.
Scheme 1- synthesis of 1, 2, 3-triazolyl-2-aminopyrimidine.
By a similar procedure, various hybrids of 1, 2, 3-triazolyl-2-aminopyrimidine were synthesized wherein a green solvent was used making the process safe and more environment friendly.
Researchers suggested that water seems to be a good solvent to carry out this reaction since the salts used in the synthesis viz. guanidine hydrochloride and sodium hydroxide are highly soluble in water, thus promoting the reaction.
(Ali Ramazani, et al., 2015) proposed synthesis of propanamide derivative using water as a green solvent. Herein, the researchers have found out a novel method facile, catalyst-free one-pot and three-component synthesis of highly substituted propionamide derivative using water as a solvent in presence of ultrasound instead of heat or stirring thus making it energy efficient. The synthesis was thus a clean, rapid and energy efficient
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Preparation Of L-Phenylalanine Lab Report
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Acetylsalicylic Acid Synthesis Lab Report
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O-Vanillin Lab Report
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Synthesis Of 3-Nitrochalcone Lab Report
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Recrystallization Of Acetanilide Essay
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5-Trifluoromethyl Oxazole
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