Oxytetracycline Hydrochloride Lab Report
Conductometric, Spectrophotometric and In Vivo Investigation of the Interaction of Ca(II) Ion with Oxytetracycline Hydrochloride
Elsayed M. Abou Elleef1* Esam A. Gomaa2 Amr Negm3 and Elsayed T. Helmy4
1Basic Science Department, Delta Higher Institute for Engineering & Technology, 35681-Dakhlia, Mansoura, Egypt. s.abouelleef@yahoo.com
2Chemistry Department, Faculty of Science, Mansoura University, 35516-Mansoura, Egypt.
3Biochemistry Department, Faculty of Science, Mansoura University, 35516-Mansoura, Egypt.
4Basic Science Department, Mansoura College, Higher Institute of Engineering & Technology, Dakhlia, Mansoura, Egypt.
Abstract
The interaction of antibiotic oxytetracycline hydrochloride (OTC) with calcium ion in water and methanol
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Work of this type has been done by Job who developed the method of continuous variation [47]. This Method makes use of any measurable additive property of two species [48, 49]. Any complex formed by the two species must give a value for the separate species. The simple application of the method involves equilibrium of type:
A + nB = ABn
Where A represents a metal, B a coordinating group and ABn a complex. Solutions are prepared in which the mole fraction of the compounds are varied and the total number of moles of both, is kept constant. If there is no complexing, the plot of extinction coefficient or absorbance against mole fraction or concentration is a straight line but if a complex is formed, the plot deviates from linearity. The deviation is maximum at mole fraction corresponding to the composition of the complex. When the deviation is plotted against mole fraction, the maximum point gives the desired composition. The conclusion may be verified by repeating the process at other wavelengths. Since the position of the maximum is independent of
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This is an interesting result because calcium forms a complex ion in aqueous solutions with OTC, but the same investigated compounds doesn’t show significant decrease in serum ionized calcium due to the ability of the compounds to form complexes with calcium at physiological conditions i.e. (inside living organisms).So administration of those compounds has no side effect on serum ionized calcium on developing any hypocalcaemia related
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