Spironolactone Lab Report

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FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF SPIRONOLACTONE GUPTA ANKUR1 , INDURKHYA ARPNA1 , CHATURVEDI S.C1 1Sri Aurobindo Institute of Pharmacy Indore-Ujjain State Highway, Near MR-10 Crossing Indore, 453111, Madhya Pradesh (India) Email id – ankur.gupta218@gmail.com ABSTRACT :- Spironolactone is aldosterone antagonist drug belonging to the category of potassium sparing diuretics administered orally that has absolute bioavailability of only 68% due to the poor aqueous solubility. The main aim of the present work was to develop a self emulsifying drug delivery system (SEDDS) to enhance the oral absorption of spironolactone. The solubility of spironolactone in various oils, surfactants, and co surfactants…show more content…
spironolactone was formulated as a SEDDS in an attempt to increase its solubility. An optimized formulation of SEDDS containing spironolactone was developed through the construction of In-vitro drug release study and solubility study. SEDDS show increase in solubility compared to pure drug formulation Thus, the above findings support that the utility of SEDDS. SEDDS can be promising as future, dosage form for drugs which suffer poor aqueous solubility (BCS class II drugs). REFERENCES 1. Ahmad A.W, Shahba K.M, Fars K.A. SNEDDS for oral delivery of Cinnarizine design optimization and in-vitro assessment. American Associate of Pharmaceutical Science.2012; 3(2): 1-5. 2. Borhade V, Nair H. Self emulsifying drug delivery system: A tool in solubility enhancement of poorly soluble drugs, global Journal of Pharmaceutical Sciences 2012; 2(3):1-2 3. Date A. A, Nagarsenker M. S. Design and Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Cefpodoxime Proxetil. International Journal of Pharmacy. 2007; 329 (2):

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