Swot Analysis Of Aldosterone

FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF SPIRONOLACTONE
GUPTA ANKUR1 , INDURKHYA ARPNA1 , CHATURVEDI S.C1
1Sri Aurobindo Institute of Pharmacy Indore-Ujjain State Highway, Near MR-10 Crossing Indore, 453111, Madhya Pradesh (India)
Email id – [e-mail]
ABSTRACT :- Spironolactone is aldosterone antagonist drug belonging to the category of potassium sparing diuretics administered orally that has absolute bioavailability of only 68% due to the poor aqueous solubility. The main aim of the present work was to develop a self emulsifying drug delivery system (SEDDS) to enhance the oral absorption of spironolactone. The solubility of spironolactone in various oils, surfactants, and co surfactants

Spironolactone causes increased amounts of sodium and water be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive agent. Approximately, 40% of the new drug candidates in development today are water insoluble and associated with poor bioavailability. There were various formulation approaches reported to overcome these problems; these include the use of drug nanoparticles, solid dispersions, micronization, lipids, surfactants, complexation with cyclodextrin, and permeation enhancers . Majority of these approaches have their limitations because of the need for specialized equipment, complicated manufacturing process, longer processing time, and regulatory complexity. Lipid-based formulation approaches, particularly the self- emulsifying drug delivery system (SEDDS), are well known for their potential as alternative approach for delivery of hydrophobic drugs.
The main objective of the study is to increase oral bioavailability of spironolactone using a lipid- based formulation i.e, self emulsifying drug delivery system. In the present work it is proposed to formulate and evaluate self emulsifying drug delivery system of spironolactone in order to achieve a better dissolution rate and preventing the drugfrom

spironolactone was formulated as a SEDDS in an attempt to increase its solubility. An optimized formulation of SEDDS containing spironolactone was developed through the construction of In-vitro drug release study and solubility study. SEDDS show increase in solubility compared to pure drug formulation Thus, the above findings support that the utility of SEDDS. SEDDS can be promising as future, dosage form for drugs which suffer poor aqueous solubility (BCS class II drugs).
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