REDUCTION OF MORPHINE IN POPPY SEEDS THROUGH FOOD PROCESSING FOR ENHANCING NUTRITIONAL QUALITY OF FOOD PRODUCTS Ankita Sharma1, Parul Sharma2 and Nimali Singh3 1. Research Scholar, Department of Home Science, University of Rajasthan; 2. Assistant Professor, Department of Food Science and Nutrition, Banasthali University; 3. Associate Professor, Department of Home Science, University of Rajasthan, Jaipur ABSTRACT INTRODUCTION: Poppy seed is an oilseed obtained from the opium plant (Papaver somniferum). It is one of the oldest known painkillers consisting of many alkaloids (morphine, codeine etc.)
Dose-Response infection model parameters per route of administration using critical or indicator microorganisms. Microorganism Best fit model Optimized parameter(s) LD50/ID50 Route Dose units Reference Escherichia coli enterohemorrhagic (EHEC): Dose Response Models exponential k=2.18E-04 3.18E+03 oral (in food) CFU Cornick & Helgerson (2004) Escherichia coli: Dose Response Models beta-Poisson α = 1.55E-01 , N50 = 2.11E+06 2.11E+06 oral (in milk) CFU DuPont et al. (1971) Table 2. Preservative efficacy test (PET) results of selected pharmaceutical products based on USP, 2010. Dosage Form Test Microorganisms Testing Days Antimicrobial Components Antiseptic mouth wash solution S. aureus* >3.40 >3.40 Hexetidine and Ethanol 96% E. coli* >3.00 >3.00 P. aeruginosa* >3.30 >3.30 B. cepacia*,ψ >3.07 >3.07 C. albicans* >3.70 >3.70 A. brasiliensis 0.25 1.50 * = Microorganisms that have not been recovered at any stage of the test from the recovery medium.
Various drugs like Neostigmine, Opioids, Hyaluronidase, and Clonidine etc.1-4 have been added to local anaesthetics in order to modify the block in terms of quick onset, good quality, prolonged duration and post-operative analgesia. But these are not without adverse systemic effects or of doubtful efficacy. Midazolam, a water-soluble benzodiazepine is known to produce antinociception and to enhance the effect of local anaesthetic when given epidurally or intrathecally. Midazolam produces this effect by its action on Gamma Amino Butyric Acid-A (GABA-A) receptors. GABA receptors have also been found in peripheral nerves.
DEVELOPMENT AND VALIDATION OF ZERO AND FIRST ORDER SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF IN EMPAGLIFLOZIN BULK AND PHARMACEUTICAL DOSAGE FORM N.PADMAJA2, G.VEERABHADRAM1 * Department of Chemistry, University College of Science, Osmaina University, Hyderabad, India. Faculty of Pharmacy, University College of Technology, Osmaina University, Hyderabad, India. Corresponding Author Email: firstname.lastname@example.org ABSTRACT Objective: Two simple accurate and precise, linear zero and first order Spectrophotometry methods were developed and validated for the estimation of Empagliflozin in bulk and pharmaceutical dosage form. Methods: The estimation of Empagliflozin was carried out by using the zero order and first order derivative values and measured at 275 nm and 282 nm correspondingly. The estimation of the Empagliflozin was carried out by regression equations with the standard solution, sample solution.
FORMULATION, CHARACTERIZATION AND EVALUATION OF SELF-EMULSIFYING DRUG DELIVERY SYSTEM OF ROSUVASTATIN CALCIUM NIRAV KHANT*, MEENAKSHI PATEL, MANALI PARIKH Babaria Institute of Pharmacy, Varnama, Vadodara. Address: Babaria Institute of Pharmacy, Varnama, Vadodara-391240 E-mail: email@example.com ABSTRACT The objective of this work was to develop Solid self-emulsifying drug delivery system (Solid SEDDS) for increasing the bioavailability of poorly water soluble drug Rosuvastatin Calcium. Selection of formulation components was done on the basis of their drug solubilisation capacity. Pseudo ternary phase diagrams were constructed to identify the efficient self-emulsification region. Liquid SEDDS were prepared and optimized on
Development and Validation of Analytical Method for Simultaneous Estimation of Diclofenac potassium and Serratiopeptidase in Pharmaceutical Formulation Dhara Parekh*, Alpesh B. Limbasiya, Pankaj P. Kapupara, Ketan V. Shah Department of Quality Assurance, School of Pharmacy, RK University, Rajkot-360 020, Gujarat, India “*Address for correspondence”: School of Pharmacy, RK University, C/O: R.K. College of Physiotherapy Center, Near: Bhaktinagar Circle, Rajkot-360002, Gujarat, India. Email Address: firstname.lastname@example.org Mo. - +91-9726933535 ABSTRACT: A simple and novel method has been developed for simultaneous estimation of Serratiopeptidase (SER) and Diclofenac potassium (DCL) by spectrophotometry. The method developed is sensitive, rapid, accurate and economical. In the method, concentration of Diclofenac potassium was determined directly from calibration plot by measuring absorbance at 300 nm and concentration of Serratiopeptidase was determined after correction of absorbance of Diclofenac potassium at 300 nm.The
Detection and quantitation limits Sensitivity of the developed method was evaluated by calculating the detection and quantitation limits. These limits were calculated using the formula; LOD=3.3σ/S and LOQ=10σ/S for limits of detection and quantitation, respectively, where σ is the standard deviation of intercept and S is the slope of calibration curve. The obtained LOD and LOQ values were 0.022 and 0.068 μg mL-1, respectively (Table 2). These values indicates that the high sensitivity of the developed method as it can quantify a concentration of the studied drug down to the nano-gram level. 3.5.3.
carboxymethylcellulose sodium and xanthan gum. This might be due to amorphous state of the drug in solid dispersions, wettability improvement, reduction in particle size and increase in the effective surface area over which the drug distribution increases. The results of study demonstrated the suitability of selected polymer xanthan gum and NaCMC in the preparation of solid dispersions as effective carrier for increasing solubility. As these swellable polymers are regularly used in conventional solid dose preparations and herbal polymer is readily available at low cost, this ensures about the availability, feasibility in use and cost effectiveness of the formulations. Overall, this research work presents a very simple but effective technique for dissolution enhancement using very common polymers.
5. RESULTS AND DISCUSSION 5. RESULTS AND DISCUSSION The present study was undertaken to formulate a extended release tablet dosage form containing a core tablet on which polymeric layers are coated which extends the release. These polymeric layers undergo different rates of swelling and drug release by diffusion process. A) API Characterization: Table 5.1: Organoleptic properties of Bupropion HCl S.No.