Spray Congealing Process
This process consists of suspending the drug particles in a low-melting polymer or wax and pumping the consequential slurry through an atomizer into a spray dryer in which cold air is circulated. The slurry droplets thicken on coming in contact with the air and are collected in the same manner as the spray-dried product. The spray congealing process requires a much higher ratio of coating agent to active material than does spray drying because only the molten coating agent constitutes the liquid phase. Encapsulation of drug-containing cores and granules (resins) in the manufacture of reservoir-type oral controlled released product can be accomplished by the following coating methods: 123-125
c) Pan Coating For encapsulation, Pan coaters are
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Process steps involved: 1. Liquid supply is atomized into fine droplets. 2. These fine droplets are mixed with heated gas stream, allowing the liquid to disperse and leave dried solids powder. 3. Finally, the dried powder is separated from the gas stream and collected. The final product usually has the same size and shape as the atomized droplet.
e) Air suspension coating (Wurster Process) 135 With the high demand for encapsulated materials in the global market, fluid-bed coaters have become more popular. They are used for encapsulating solid or porous particles with optimal heat exchange the liquid coating is sprayed onto the particles and the rapid evaporation helps in the formation of an outer layer on the particles. The thickness and formulations of the coating can be obtained as
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pH: with the use of a pH meter.
Viscosity: by using a cone and plate viscometer. the temperature was controlled at 30 ± 1°C and the viscosity was determined at 50 rpm
Redispersibility: the evaluation of redispersiblity was carried by rotating in screw-capped test tube 360°C at 20 rpm. The number of revolution was recorded till the suspension restored to homogeneity.
Zeta potential: The zeta potentials (Z-potential) were measured at 25°C using a streaming potential analyzer Values of the Z-potential were calculated from the Helmholtz-Smoluchowski equation
Determination of in vitro drug release: Five milliliters of uniformly dispersed suspension was taken and placed straight into a dissolution container. Then, the solution was agitated and withdrawn at prearranged interval to evaluate for drug release by HPLC
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