Suamous Cell Carcinoma Research Paper

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Abstract

Introduction: Malignant tumor of the squamous epithelium is known as the squamous cell carcinoma. It has been a major cause of morbidity and morality worldwide. It is causing a major health problem across the world. Among the most common cancers seen in both Indian men and women as can be gauged from the records of the National Cancer Registry Programme. From the clinical point of view squamous cell carcinoma are important. They have a wide variety of fields, including medicine, pathology, surgery, nuclear medicine, and radiation therapy. It have been identified that oral cavity squamous cell carcinoma contains cancer stem cells. Cancer stem cells have the ability for proliferation and perpetual self-renewal, producing downstream
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Among them 20 are normal healthy individuals and 20 are patients with OSCC. Informed consent was obtained from the patient before sample collection. 5ml of fasting venous blood was collected and centrifuged in 3000rpm for 10 minutes. Then serum was separated and then it is analysed for serum cholesterol by Cholesterol esterase-Oxidase method, Serum triglycerides by colorimetric enzymatic method, HDL-c by Phosphotungtic acid method, LDL-c and VLDL-c were calculated by Friedwald’s formula.

Results: There is a significant increase in LDH (p<0.005) levels in OSCC patients when compared with healthy controls, by the influence of OSCC on LDH metabolism.

Conclusion: Our findings suggest that assessment of LDH can be used an effective biochemical diagnostic tool for the manifestation of OSCC and other type of malignancy in patients.

Key words: OSCC, cell damage, carcinoma, oral cavity, lipid profile status.
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The fasting blood lipid profile, including total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL), was evaluated [7].

Mitochondrial enzymes such as SDHA, SDHB, ATP synthase are found in increased expression in oral squamous cell carcinoma patients when compared with normal oral mucosa. This study is done when the investigation on cancer metabolism-related proteins in the carcinogenesis of oral squamous cell carcinoma is conducted [8].

Oral squamous cell carcinoma patients in early stage are observed with greater level of lactic acid. More energy is required for the excessive proliferation of cancer cells, therefore large amounts of lactic acid is often produced by the tumors by carrying out glycolysis even under aerobic conditions [9].

Major public health problem worldwide is represented by the cancers of the upper aerodigestive tract. In 2014, 73,240 new cases were diagnosed , with an estimated mortality of 27,450

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