Application Of Stereochemistry stereochemistry 9/10/2014
Submitted by: Amna Arshad
Submitted to: ma’am Rubina
Semester : 5th
Stereochemistry
Stereochemistry is branch of chemistry which deals with 3D (three dimensitional) arrangement of atoms and molecules.
Stereoisomers
Stereoisomerism defined as two or more isomerism has same molecular formula but different structure formula. Stereochemistry basically describe the stereoisomers and explain the whole spectrum of inorganic, organic, physical, biological and particularly supramolecular chemistry. Enantiomers
Enantiomers defined as two compounds (stereoisomers) which are mirror image of each other. Chiral
It is a type of stereoisomers in which the structure and its mirror image are not
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Most of molecules present in living organisms are amino acid, carbohydrate and phospholipids are Chiral molecules.
BioMolecules
All BioMolecules are Chiral in nature and have application in stereochemistry. BioMolecules are like amino acids, proteins, carbohydrates (sugars) are Chiral in nature. Proteins are built from L-amino acids are Chiral in nature and drugs, taste, biopharmaceuticals are Chiral in nature.
Role of Stereochemistry as Drug
Chiral Drugs
Chiral drugs play important role in pharmaceuticals. Chiral drug give benefits to human beings. It has greater selectivity for their biological targets so it improved therapeutic indices and adverse or dangerous effect reduces by using chiral drugs present in medicine have great dosing frequency. Chiral drug decreased individual variability.
Captopril
It is stereoisomers or chiral drug play role in human body and used for treat high blood pressure of human body. Its structural formula is
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Glycogen is present in form of alpha branched chain of glucose molecule with two bonds 1-4 glycoside bond and 1-6 glycoside bond. Human have little quantity of glycogen present in muscles and liver. It is present when high blood sugar levels. Insulin secretes pancreas which converted glucose to glycogen and it is use as main form of energy. Humans use glycogen in energy form. Glucose
The glucose is a monosaccharide present in diet in form of hexose monosaccharide. It is present in fruits , vegetables, honey etc. D-glucose (C6H12O6) is a blood sugar. Glucose store in liver and muscles in form of glycogen and provides the energy of human beings. Fructose
Fructose has molecular formula of C6H12O6. Fructose has same molecular formula as the molecular formula of Glucose but different structure. The structure of fructose differs from glucose at carbon 1 and 2 positions due to change of carbonyl group. Fructose is sweet sugar occur in nature. It is present in fruits and vegetables like tomato, potato etc. fructose is basically isomers of glucose and fructose converted into isomer glucose then it enter in blood stream. It is a source of energy for human beings.
Web. 26 Oct. 2015.www.study.com Disaccharides, or sometimes called double sugar, is composed of two molecules of simple monosaccharides connected to each other. Disaccharides are crystalline water-soluble compounds. The monosaccharides within molecules are connected by a bond called, glycosidic. The three main disaccharides are lactose, sucrose, and maltose.
People say sugar is sugar, but the amounts of sugar in HFCS are higher than those in cane sugar. “Health byte” explains, “[T]he amounts of fructose in processed sugar are large: table sugar has equal amounts of fructose and glucose, and high-fructose corn syrup contains 65% fructose. Both are common
Why do we need it? Medical term of sugar is glucose, which we get from food and our liver. To make it easier to understand, glucose it a fuel needed to produce an energythat helps body tissues to build up our muscles. There is number of risk factors of diabetes already known for society, such as: family history, genetics, age, geography.
According to Dr. Lustig, fructose is a major threat to the well being of people because it is an economic evil. Fructose is extremely inexpensive to produce, especially in large quantities, and is used in most foods we eat today. Avoidance of fructose consequently becomes difficult and majority of the population then ingests excessive amounts of the sugar. Metabolization of fructose causes the suppression of the effects of ghrelin and slows stimulation of insulin and leptin. Since the biochemical processes that involve ghrelin, insulin, and leptin are compromised the feeling of hunger doesn’t seem to leave or the sense of being full doesn’t appear.
In terms of composition, HFCS is nearly identical to table sugar (sucrose), which is composed of 50 percent fructose and 50 percent glucose. Glucose is one of the simplest forms of sugar that serves as a building block for most carbohydrates. Fructose is a simple sugar commonly found in fruits and honey. ” says Iowacorn.com. basicly HFCS is made from corn fructose is a sugar found in honey and fruit. For example soda candy and frozen junk food have high levels of fructose corn syrup.
Lustig (2012) explains and suggests the following: Authorities consider sugar as ‘empty calories’ but there is nothing empty about these calories. A growing body of scientific evidence is showing that fructose can trigger processes that lead to liver toxicity and a host of other chronic diseases… they [Government] must consider limiting fructose and its main delivery vehicles, the added sugars HFCS (high-fructose corn syrup) and sucrose, which pose dangers to individuals and to society as a whole. (p.28) Another process that occurs in the body is that, “sugar dampens the suppression of the hormone ghrelin, which signals hunger to the brain…interferes with the normal transport and signaling of the hormone leptin, which helps to produce the feeling of satiety…and it reduces dopamine signaling in the brain’s reward center” (Lustig, 2012, p. 28). Though these are only a few examples and there are many more such as sugar feeding cancer cells, it should give you a basic understanding of just how bad sugar is for the
Our bodies take in the glucose and turn it into energy we can then use. When we let glucose in, we are raising our insulin and glucose levels. Insulin is the hormone in people’s bodies that grants glucose access into our bloodstreams. However, insulin keeps our blood levels from raising or lowering, and it stores the fat to use for energy later on. Unfortunately, people have no control over the insulin function, though they do have control over the types of food they eat that contain certain amounts of glucose.
Although sugar is seen as the public’s number one enemy. Nancy Appleton a writer who wrote Suicide By Sugar, blames the government and certain food industries for creating advertisements promoting bad sugars. But also in charge of creating the child obesity epidemic in America, endangering young children’s health in the U.S. Since some foods have artificial sugars, sugar decreases the quality of life in the U.S. Stated by the Journal of the American Heart Association Internal Medicine, “People who consumed more than a quarter of their daily calories as sugar… twice as likely to die” (Health, Richards). This statistic by a credible source pulls the audience in because they are part of that population who intake sugar and can die faster by consuming it.
Testing for the Presence of Macromolecules in McDonald’s Happy Meals Clayton Wagoner MST Biology White 4 duPont Manual High School Introduction Carbohydrates, lipids, proteins, and nucleic acids are organic molecules found in every living organism. These macromolecules are large carbon based structures. The macromolecules are assembled by joining several smaller units, called monomers, together through a chemical reaction called dehydration synthesis. The resulting polymer can be disassembled through the complementary process called hydrolysis.
Intro It’s a sunny, warm day kids playing outside and healthy, well that was back then. It’s still warm and sunny but now, kids are inside glued to their electronics and not healthy. Why? What caused this?
Glucose, which is a six-carbon sugar, is at that moment divided into two molecules of a three carbon sugar. The breaking down of glucose, takes place in the cell’s cytoplasm. Glucose and oxygen are produced from this breakage, and are supplied to cells by the bloodstream. Also produced by glycolysis are, 2 molecules of ATP, 2 high energy electron carrying molecules of NADH, and 2 molecules of pyruvic acid. Glycolysis happens with or without the presence of oxygen.
However, all proteins are constructed from the same set of 20 amino acids linked in unbranched polymers. The covalent bond that exists between amino acids is called peptide bond, hence a polymer of amino acids is named polypeptide. A protein is a biological functional molecule made up of one or more polypeptides which is folded and coiled into unique three-dimensional structure. In laboratory, it is important to measure the concentration of proteins for research investigations. Biuret test is adopted to quantify proteins in fluid by using a spectrophotometer.
The results of the phenol-sulfuric acid analysis conducted in this experiment suggest that the data acquired was relatively precise but inaccurate with respect to the given carbohydrate concentrations of the soda and Gatorade samples. Using a standard curve generated from a glucose solution with a known concentration, the carbohydrate concentration of the samples was determined (in terms of glucose) and a low coefficient of variation was calculated. However, a high percent relative error was apparent in the analysis of both samples. This may have been due to the fact that the analysis was conducted assuming glucose was the carbohydrate of interest, while, in fact, a significant portion of the monosaccharides would have existed as fructose (a
Sugar/ glucose is an important carbohydrate that can be made during photosynthesis from water and carbon dioxide, using energy from sunlight. Carbon dioxide is given off as a waste product when energy is released by the breaking down of glucose. This can be used by plant cells in the process of photosynthesis to form new carbohydrates. Yeast is a single-celled fungus that can break down sugars (glucose) to help produce carbon dioxide. Research Question
• Carbohydrate metabolism: • Gluconeogenesis: The formation of glucose from certain amino acids, lactate and glycerol. • Glycogenolysis: The formation of glucose from delglucógeno. • Glucogenosíntesis: The synthesis of glycogen from glucose. • Elimination of insulin and other hormones.