N-Alkanoic Acids
Literature Review 2.6 Summary of Literature Review This literature review can be summarised as follows: In recent years. There is a noticeable increase in the amount of drugs on the market that are poorly water soluble, and therefore have a poor bioavailability. This can be partly put down to advances in synthesis technology and development of drugs, resulting in the formation of larger, bulkier drugs which are more complicated and difficult for the body to absorb. Crystal engineering and crystallisation are effective methods of improving the bioavailability of poorly water-soluble drugs. Crystallisation is a method by which a solid can be separated from its solution while being purified, and is driven by supersaturation. A high level …show more content…
Davey, R. J., Black, S. N., Logan, D., Maginn, S. J., Fairbrother, J. E. and Grant, D. J. W. (1992) ‘Structural and kinetic features of crystal growth inhibition: adipic acid growing in the presence of n-alkanoic acids’, Journal of the Chemical Society, 88, 3461-3466. De Waard, H., Friklink, H. W. and Hinrichs, W. L. J. (2011) ‘Bottom-Up Preparation Techniques for Nanocrystals of Lipophilic Drugs’, Pharmaceutical Research, 28(5), 1220-1223. Durrington, P.N. (2012) ‘Cholesteryl Ester Transfer Protein (CETP) Inhibitors’, British Journal of Cardiology, 19(3), 126-133. Encyclopaedia Britannica (2016) ‘Nucleation – Crystallography – Britannica.com’ [online], available: https://www.britannica.com/science/nucleation [accessed 07 Nov 2016]. Farlex, Inc (2017) Crystal growth – Article about crystal growth by the Free Dictionary’ [online], available: http://encyclopedia2.thefreedictionary.com/crystal+growth [accessed 13Feb17]. García-Arieta, A. (2014) ‘Interactions between active pharmaceutical ingredients and excipients affecting bioavailablilty: Impact on bioequivalence’, European Journal of Pharmaceutical Sciences, December,
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Long Lab Report
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Unknown Compounds
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Unknown Compounds
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Acetylsalicylic Acid Synthesis Lab Report
704 Words | 3 PagesLab Report 5: Acetylsalicylic Acid (Aspirin) Synthesis Name: Divya Mehta Student #: 139006548 Date Conducted: November 19th 2014 Date Submitted: November 26th 2014 Partner’s Name: Kirsten Matthews Lab Section: Wednesday 2:30 L9 IAs Name: Brittany Doerr Procedure: For the procedure, see lab manual (CH110 Lab Manual, Fall 2014) pages 96-98. Wilfrid Laurier University Chemistry Department. Fall 2014. Acetylsalicylic Acid (Aspirin) Synthesis.
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1124 Words | 5 PagesIn particular, the formulation of rosuvastatin, molecule which is generally lipophilic, poses real problems owing mainly to their low solubility in aqueous liquid pharmaceutical excipients, to their propensity to precipitate or recrystallize in aqueous solution and to their low solubility in the fluids of the gastrointestinal tract from which they must be absorbed. The bioavailability of an active ingredient also depends on its concentration in the gastrointestinal fluid, said concentration itself being dependent on the release of the active ingredient. In particular, the more lipophilic an active ingredient is, the less tendency it has to migrate in gastrointestinal fluids.
Polypharmacy In The Elderly Essay
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Unknown Compounds
1027 Words | 5 PagesFirst, two grams on an unknown white compound were given. The possible compounds the known could be were CaCO3, KNO3, NH4Cl, CaCl2, K2SO4, (NH4)2SO2, Ca(NO3)2, NaC2H2O2, K2CO3, MgCl2, Na2CO3, 0.1 M AgNO3, MgSO4, NaCl, 0.2 M BaCl2, KCl, NaSO4, Mg(s), HCl, HNO3, NaOH, HC2H3O2, H2SO4, and KOH. The solubility test required using a scale to measure .575 of our unknown white compound. The unknown compound was measured in a 100 mL beaker.
Otc Drug Persuasive Speech
1600 Words | 7 PagesImagine a typical school day. You wake up in the morning and prepare for the day, and there it is. You can feel your nerves pulsating through your head as it spins hysterically. The day has just begun, and you already have a headache. This isn’t new to you, so you simply go along with it as it happens every other day.
Counterfeit Medication Research Paper
614 Words | 3 PagesCounterfeit Medications By Yolanda Smith, BPharm A counterfeit medication or drug is defined as a pharmaceutical product that is produced and sold with the intention to deceive the consumer about the origin, authenticity or efficacy of the product. This has the potential to be dangerous for consumers as the formulation may contain unusual ingredients or quantities of the ingredients, which can affect the effect of the medication in the body. Additionally, mislabeling of the pharmaceutical goods may also cause problems Issues with Counterfeit Medications There are several different errors that may be intentional or accidental that may cause a medication to be classified as counterfeit.
Increasing Medication Errors
1488 Words | 6 PagesRaising the Awareness of Medication Errors Introduction Medication errors are the 3rd leading cause of death in the United States, ranked behind heart disease and cancer. 1.3 million people are injured each year because of medication errors (Melissa Conrad Stoppler, 2014). Four out of five adverse events take place in hospitals. An adverse event is “an injury caused directly by medical management rather than the underlying disease or condition of the patient” (Kohn LT, Corrigan JM, Donaldson MS, 2000). Medication errors can take place in hospitals, nursing homes, doctor offices, at home, or while receiving drugs from a pharmacy.
Benzoic Acid Lab Report
767 Words | 4 PagesAbstract The unknown concentration of benzoic acid used when titrated with standardized 0.1031M NaOH and the solubility was calculated at two different temperatures (20◦C and 30◦C). With the aid of the Van’t Hoff equation, the enthalpy of solution of benzoic acid at those temperatures was determined as 10.82 KJ. This compares well with the value of 10.27KJ found in the literature.
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