Summary Of Literature Review On Nannocrystals

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Literature Review

2.6 Summary of Literature Review
This literature review can be summarised as follows: In recent years. There is a noticeable increase in the amount of drugs on the market that are poorly water soluble, and therefore have a poor bioavailability. This can be partly put down to advances in synthesis technology and development of drugs, resulting in the formation of larger, bulkier drugs which are more complicated and difficult for the body to absorb. Crystal engineering and crystallisation are effective methods of improving the bioavailability of poorly water-soluble drugs. Crystallisation is a method by which a solid can be separated from its solution while being purified, and is driven by supersaturation. A high level of supersaturation results in the formation of small crystals. This project aims to produce nanocrystals as they are effectively absorbed by the body thanks to their larger surface area, making them an effective method of increasing drug bioavailability. Antisolvent crystallisation is the method used in this project to produce nanocrystals, as this method results in a high level of supersaturation. This is caused by the quick addition of a solvent in which the solute does not dissolve to a pre prepared solution of the solute. The resulting size of the nanocrystals can be altered by altering the process parameters of the experimentation. The size of the crystals produced will be measured using an instrument called the Zetasizer

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