Swelling Index Lab Report

for 1 min.

Swelling index:

Swerlling of tablet excipients particles involving the absortion of a liquid resulting in an increase in weight and volume. Liquid uptake by the particle may be due to saturation of capillary spaces within the particles or hydration of macromolecule. The liquid enters the particles through pores and bind to large molecule, breaking the hydrogen bond and resulting in the swelling of particle. The extent of swelling can be measured in terms of % weight gain by the tablet. For each formulation batch, one tablet was weighed and placed in a beaker containing 200 ml of buffer media. After each

33 interval the tablet was removed from beaker and weighed again up to 9 hrs. the swelling

index was calculated using following

= Swelling index

Wt = weight of tablet at time t

Wo = Weight of tablet before placing in the beaker

Wash off test:

The mucoadhesive properties of the tablets were evaluated by an in-vitro adhesion

testing method known as wash-off method. Piece of intestinal mucosa were mounted on

to glasslides were connected with suitable support. About 2 tablets attached on to the

slide and the support was hung on to the arm of a USP tablet disintegrating test machine.

By operating the disintegrating test machine was given a slow regular up and down movement in the test fluid (phosphate buffer pH 7.4) at 37oC temperature. A the time of

detachment of both tablets was noted down.

A batch of 60 tablet was prepared in each case a blend of 3 gm of glipizide with required amount of polymers. Which were then granulated along with a solvent blend of water and ethanol (1:1). Firstly required amount of drug and polymer were taken in a mortar and pestle for the trituration. Then the solvent was added drop wise with continuous stirring until the wet mass was formed. Then the wet masses were passes though 12 mesh sieve and granules were dried at 60c for 4 hours. The dried granules after blending with talc and mg stearate in a laboratory cube blender for 5 mins. Then granules were compressed into 300 mg tablet of hardness 6-7 kg/cm3 on a tablet compression machine using 10 mm biconcave shaped