Tablets Lab Report

for Drug Loaded Multi particulates Physical Description Bulk Density and tapped density. Angle of repose Compressibility Index Hauser’s ratio Assay Dissolution studies

5.4.1 ASSAY: STANDARD SOLUTION: Label claim amount of pure drug is dissolved in 100ml of water. As the drug is highly soluble in water.

10 tablets are finely powdered and transfer powder equivalent to that of average weight of tablet and transferred to homogenization vessel and add 50ml of water and homogenize, finally make up the volume using water as diluents. Measure the absorbance of the test and standard using UV spectroscopy and analyze the drug content comparatively.

After the evaluation of drug loaded multi particulates, the optimized formulation was taken

The important parameters in the evaluation of tablets can be divided into physical and chemical parameters.

5.4.2 (A) Physical appearance:

The general appearance of tablets, its visual identity and overall elegance is essential for consumer acceptance. The control of general appearance of tablet involves measurement of number of attributes such as tablet size, shape, color, presence or absence of odor, taste, surface texture and consistency of any identification marks.

5.4.2 (B) Hardness test: This is the force required to break a tablet in a diametric compression. Hardness of the tablet is determined by Stock’s Monsanto hardness tester which consists of a barrel with a compressible spring. The pointer moves along the gauze in the barrel fracture. The tablet hardness of 5 kg is considered as suitable for handing the tablet.

Fig: 2. Monsanto hardness tester

5.4.3 (C) Tablet size and

Vernier Caliper

5.4.4 (D) Friability:

This test is performed to evaluate the ability of tablets to withstand abrasion in packing, handling and transporting. Initial weight of 20 tablets is taken and these are placed in the friabilator, rotating at 25 RPM for 4min. The difference in the weight is noted and expressed as percentage. It should be preferably between 0.5 to 1.0% % Friability= (W1-W2×100)/W1 Where, W1= weight o f tablets before test W2 = weight of tablets after test

Fig: 4. Roche friabilator

5.4.5 (E) Weight variation of Tablets:

It is desirable that all the tablets of a particular batch should be uniform in weight. If any weight variation is there, that should fall within the prescribed limits. Table no .12. Acceptance criteria for tablet weight variation (IP)

Average weight of tablet(mg) Maximum % difference allowed

80 or less than 10

80-250 7.5

More than 250