Tamsulosin Case Study

Objective: the aims of this study to evaluate the efficacy of Tamsulosin 0.2mg in post shock wave lithotripsy of renal pelvic Stone ≤ 2 cm.
Patients and methods: Prospective randomized placebo-controlled double-blind clinical study was conducted in shock wave lithotripsy (SWL) outpatient unit on 106 patients .After successful SWL they were divided into, two groups; Placebo group and Tamsulosin 0.2mg group. Then follow up for 2, 4 and 6 weeks all patients completed the follow-up period except 6 patients were excluded from the study. Results Stone criteria of both groups showed no significant difference. Follow-up results after 6 weeks showed no statistically significant difference in the overall stone free rate for stones sized ≤ 1cm (P=0.856) but the Mean clearance time was higher in the placebo group than tamsulosin group (P =0.523). The clearance rate for stones sized 1-2cm within 2weeks was higher in the tamsulosin group than the control group (91.7% versus 60%, respectively) it was statistically significant difference (P=0.049) but in 4 and 6 weeks shows no statistically significant difference (P =0.745), and there was no statistically significant difference as regard colic attacks, the need for analgesic , the occurrence of Steinstrasse and the need for

Conclusion: We concluded from our study that we may abort the needs for tamsulosin 0.2 mg post SWL in the renal pelvic stones ≤ 1cm but in stones sized 1- 2 cm tamsolusin 0.2 mg may significally increase the stone free rate within two weeks (P =0.049) but after 4th week tamsulosin had no superior results to placebo ,it also can significantly decrease lower urinary tract symptoms (P =0.001) ,decline the need for large dose of analgesia(P =0.027) ,decreased the occurrence of steinstrasse and facilitate its spontaneous passage