Targeted Therapy

What is pancreatic cancer? Pancreatic growth happens when unusual cells in the pancreas uncontrollably grow, framing a mass of tissue called a tumor. It can happen in the head, body or tail of the pancreas. Causes Of pancreatic cancer? Tumor is eventually the consequence of cells that wildly develop and don't die.

Stem Cell therapy could be a cure for cancer. Stem cell therapy ensures that cells lost due to chemotherapy can be regenerated faster and so increased doses of chemotherapy can be administered to cancer patients. These patients can therefore have a better chance of getting rid of all cancer cells and allow for them to recover faster. Stem cells are cells that are unspecialised, that can divide and that are able to differentiate into a specialised cell or tissue with a specific function (KUUN, L. and NORTJIE, S). The source National Cancer Institute (2015) defines cancer as the name given to a collection of related diseases, where the body’s cells begin to divide without stopping and can spread into surrounding tissues.

Chemotherapy, which involves the use of Sorafenib (Nexavar), a drug used to treat aggressive or metastatic thyroid cancer that is not responsive to radioactive iodine therapy. Possible side effects include diarrhea, weight loss, fatigue, high blood pressure, and skin rash. Other Ways of Coping with Hurthle Cell Carcinoma Treatment for Hurthle cell carcinoma can be frightening and challenging. Here are some tips to help you cope with the disease: • Discuss your feelings with a family member or friend or join a support group for cancer patients and families. • Accept help from other people.

DISCUSSIONS Hysteroscopy was done on the patient to diagnose her condition and also to take the biopsy of her endometrium. Will it cause the tumor to get spread even more during the procedure? Or is there any better option than that? First, the diagnosis should depend on the patient’s presenting complaint, symptoms, signs, and also the risk factors associated with them. In this case, she presented with postmenopausal bleeding, which endometrial carcinoma become the main differential diagnosis until it is proven otherwise.

Guidelines by NCCN for breast cancer are: Self examination at age of 25 and mammography, MRI at age of 30-35. Study Objective: The objective of this study is to control breast cancer by treating the cowdin syndrome because Cowdin syndrome is the main cause of breast cancer. 40% breast cancer is caused by Cowdin syndrome. And it is caused by mutation in PTEN gene. Now mutations of this gene are controlled by inserting the IPTEN gene which is discovered in model organism Dicyostelium discoideum.

Introduction Thrombocytosis is when you have too many platelets (thrombocytes) in your blood. Platelets are parts of blood that stick together and form a clot (thrombus) to help your body stop bleeding. Some conditions that cause inflammation, such as cancer, may trigger your body to make more platelets than normal. There are two types of thrombocytosis. Primary or essential thrombocytosis happens when abnormal cells in the bone marrow make too many platelets.

Yes it is treatable. Primary thrombocytosis is most commonly treated by taking aspirin or the medication the doctor provides. sometimes treatment requires medical procedures. To treat secondary thrombocytosis what needs to be done first is to treat the condition that is causing it. Some causes for secondary thrombocytosis are von Willebrand disease, and cancers.

A few cases have been described that have proved resistant to aggressive treatment with surgery, radiotherapy, dopamine agonists, and, occasionally, chemotherapy. In a small proportion, extracranial metastases in liver, lungs, bone, and lymph nodes have been documented. • ACTH-secreting adenomas (or corticotropinomas). ACTH stimulates the adrenal gland to make glucocorticoids (or steroids, which influence metabolism and act as anti-inflammatory and immunosuppressive agents). An oversupply of ACTH, such as that produced by this type of tumor, can cause Cushing's disease (one type of Cushing's

Working on the success of Abraxane, nab-rapamycin was also prepared. Rapamycin (also known as sirolimus) works by inhibiting the signals from intracellular kinase (mTOR) which further inhibits cell proliferation. Rapamycin also had poor solubility similar to PTX hence, nab rapamycin was prepared to overcome this barrier and increase its efficacy. The nanoformulation proved to be efficacious in preclinical studies (breast tumor xenograft model) and the drug (ABI-009) is undergoing Phase I-III trials in humans for multiple carcinomas including advanced sarcoma, advanced malignant perivascular epithelioid cell tumor, non muscle invasive bladder cancer and recurrent or refractory solid tumors [82,

Carcinogens from the environment likely contribute to a large percent of human cancers when related to lifestyle, including diet and tobacco use. Chemical carcinogenesis is a multistage process. Carcinogenic chemicals act by introducing certain genetic changes in a cell (initiation), promoting the foundation of a benign neoplasm (promotion), converting the

There are numerous parts for cardiovascular ultrasound throughout potentially cardiotoxic cancer treatment regimens. Primarily, prior to potentially cardiotoxic chemotherapy, echocardiography can safeguard that patients do not already have diminished cardiac function. Subsequently, throughout chemotherapy, cardiovascular ultrasound can monitor ventricular function to eliminate chemotherapy-induced dysfunction. Preceding, the follow-up treatment, cardiovascular ultrasound can regulate new symptoms that are potentially caused from cardiac disease. Initial discovery of diminished ventricular function permits adjustments in the chemotherapy regimen, either by increasing the break amid doses or by reducing the total cumulative dose of a theoretically toxic agent.

SRT1720 Description: EC50: 0.16 μM SRT1720 is a selective activator of SIRT1. Previous in vitro and in vivo studies using various cancer cell models show the role of SIRT1 either as an oncogene or a tumour suppressor gene. The oncogenic potential of SIRT1 is exemplified by studies indicating that blockade of SIRT1, like other HDACs, triggers growth arrest and apoptosis in breast, colon and lung cancers. In vitro: Treatment of MM cells with SRT1720 inhibited growth and induced apoptosis in MM cells resistant to bortezomib therapy without significantly affecting the viability of normal cells. Mechanistic studies demonstrated that anti-MM activity of SRT1720 is associated with activation of caspase-3, caspase-8, caspase-9, poly(ADP) ribose

C4564 Description: IC50: 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. In vitro: Previous study found that the exposure of the tumor cell lines to 3-AP before or immediately after irradiation resulted in an increase in radiosensitivity. In contrast, 3-AP could enhance the radiosensitivity of the normal fibroblast cell line only when the exposure was before irradiation.

You may need to stay in hospital for this treatment. Strontium-89 and samarium-153 is used to treat some types of secondary bone cancer (Secondary cancer in the bone is the result of cancer cells spreading to the bone from a primary tumor somewhere else in the body). Strontium can help reduce

Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. There are three main types: basal-cell cancer, squamous-cell cancer and melanoma. The first two together along with a number of less common skin cancers are known as nonmelanoma skin cancer . Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death.