Targeted Therapy

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Explain how targeted therapy works ( in the treatment of cancer), and evaluate its effectiveness in treating cancer. You may wish to focus on a specific type of cancer Name - Vipanpreet kaur Student ID - 39298 Class - HAS-3 Word count- 1223

Targeted therapy, which first became available in the late 1990s, has had a significant impact on the treatment of cancer. Currently, because of advancement in the field of technology, various types of therapies are discovered to treat cancer.
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According to Gerber (2008, p.312) the drugs involved in targeted therapy works initially by preventing the growth of cancerous cells. Targeted therapy interrupts the specific molecules which are required for growth and development of a tumor. It blocks the proliferation of cancer cells. Gerber’s (2008, p.311) studies show that the targeted therapy drugs are used to treat many malignancies including breast, colorectal, lung and pancreatic cancers as well as lymphoma, leukemia and multiple myelomas. The main two types of targeted therapy include monoclonal antibodies and small molecule inhibitors. The molecular pathways mostly targeted in the treatment of solid tumors are those of the epidermal growth factor receptor and vascular endothelial growth factor, respectively known as EGFR OR VEGF (Gerber 2008, p.314). The targeted therapy inhibits the growth of cancer cells by blocking the VEGF receptors (Gerber 2008, p.313). The signaling molecule VEGF plays an important role in angiogenesis “which means the formation of new blood vessels”. It is a family of protein growth factors that made by some tumors (Welti, et. al. 2013, p. 3190). The VEGF proteins can attach to the VEGF receptors of blood vessel cells due to which new blood vessels formed around the tumors. The blocking of this process stops angiogenesis that would form new blood vessels to feed tumors and it could grow (American cancer society 2013, para.13). Besides this, Monoclonal antibodies work by finding particular proteins on cancer cells. These antibodies utilize their anticancer effects through various mechanisms by recruiting host immune functions to attach to the target cells by binding to “legends or receptors” (Gerber 2008,

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