Tc Analysis Of Aspirin

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Acetylsalicylic acid, or commonly known as “Aspirin” is widely used as a pain reliever, anti-inflammatory agent, and an antipyretic (fever reducer). Aspirin is a considered one of the most versatile drugs known to modern medicine. Aspirin’s active component, Salicylic acid, was initially isolated by Edward Stone. He isolated salicylic acid from the barks of a willow tree and derived from willow bark extracts. Salicylic acid is not used like it used to be because of the irritable effects it has on the stomach. The form of Salicylic acid used today is known as “Aspirin” which is far less irritating to the stomach. Aspirin is a synthetic pharmaceutical drug that is non-steroidal anti-inflammatory. The physical appearance of Aspirin is a…show more content…
The TLC performed showed an appearance of a new spot which indicates that the original substances has changed in some type of way. The TLC also showed that acetic anhydride remained due to salicylic acid working as the limiting agent which means that there is an excess of acetic anhydride. The percent yield shows that not much could be determined by the 1H NMR spectrum or the TLC analysis. The 1H NMR Graph shows the that 2.5 ppm that there is a singlet or single CH3 group. Other than that, the graph is not showing anything significant structures. The purity of the product could have yielded these poor results because some of the salicylic acid did not completely react. Combining the results from TLC analysis and IR spectrum shows that a very small amount of Aspirin was prepared and the rest could have been lost during the filtration or initial steps of the experiment. Esterification involves the transformation of a carboxylic acid into an ester which is exactly what was performed in the experiment. The esterification technique is an important and reliable technique used in organic chemistry. The experiment proved that with the execution of proper techniques, esterification is the a very efficient method regardless of the results obtained in this experiment. The experiment demonstrated the effectiveness of the esterification through the synthesis of Aspirin. Esterification has many uses and various industries. The technique is used in polymer industry, fragrance and flavor industry, and to test for carboxylic acid and alcohols. The technique is used in the manufacturing of paints, medicines, and

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