Testis Lab Report

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1.1 Physiological Background: 1.1.1 Organization of the testis: The human testes are two organs of ellipsoids shape with diameters of about 2.5 × 4 cm(Foresta et Al., 2012).Engulfed by a capsule (tunica albuginea) of strong connective tissue. Thin septula testis divide the parenchyma of the testis into about 370 conical lobules(Tomova et al., 2010)The lobules consist of the seminiferous tubules and intertubular tissue, containing groups of endocrine Leydig cells and additional cellular elements (Sanjeev et al.,20005),The seminiferous tubules are coiled loops their both ends open in to the spaces of the rete testis.The fluid secreted by the seminiferous tubules is collected in the rete testis and delivered to the ductal system of the epididymis.The…show more content…
These are located within an invaginations of Sertoli cells. The Sertoli cells are connected by specialized zones of tight junctions of cellular membranes separating the germinal epithelium into a basal and luminal compartment. These specialised zones, the so-called ,tight junctions form the blood-testis barrier. Sertoli cells, investigated in histological sections, exhibit increasing amounts of lipid droplets in correlation to advanced age being an indicator of the "biological clock" of the testis (Prince…show more content…
Sofikitis&Miyagawa, 1993 18].This phenomenon leads to persistent hypo perfusion, stasis and hypoxia, and subsequent dysfunction of the spermatic epithelium(Wang, et al.2010). Another likely pathway by which a varicocele impairs testicular function regards venous pressure While increased venous pressure could limits arterial inflow in an effort to maintain normal intratesticular pressures, the experimental evidence of such mechanisms is conflicted.( Khera& Lipshultz,2008).Another consequence of increased venous pressure involves delayed of vascular drainage. Retrograde venography and radioisotope studies have demonstrated delayed vascular washout in men with varicoceles,such venous stasis likely contributes to thermal regulatory defects and accumulation of toxins thought to play Amajor role in the pathophysiology of

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