The Importance Of Chromosomic Instability

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Genomic instability is one of the characteristics of cancer cells. It consists of alterations of genes during cell division. Cancer cases in patients can result from damage to multiple genes. These genes control cell division and tumor suppressor genes. The integrity of a genome is monitored by several mechanisms including DNA damage checkpoints, DNA repair machinery, and mitotic checkpoints within the cell. If there are defects in any one of these mechanisms the result is genomic instability. A few other things that can alter the regulation of the cell cycle are posttranslational modifications of histone tails, chromatin structure, and DNA methylation. This topic continues to be a debate about what exactly the driving force of the initiation of tumors is and what causes it to progress. Genomic stability is essential for cellular integrity. Cellular integrity, in turn, prevents errors that arise from DNA replication, cellular metabolism, and carcinogenic exposure. These exposures consist of ultraviolet light, radiation, or damaging chemical substances. Many professionals believe that tumor initiation and following progression result from acquired genomic alteration within normal cells. The populations of tumor cells appear to be…show more content…
This error results in incorrect amounts of chromosomes and abnormal structures. Chromosome instability has been seen as a major cause of the majority of cancerous tumors but it has not been proven whether or not it is considered an early step or a final demonstration of the progression of cancer. The equal segregation of chromosomes during the process of mitosis is a major factor in the upkeep for maintenance in genomic stability. If it does not happen successfully it can lead to cell death known as apoptosis or malignant transformation. This segregation during cell division is monitored by several

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