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Drosophila Importance Of Locomotion

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Locomotion forms an integral part of a living being's survival strategy. From catching prey, courtship, escaping predators, getting through harsh weather conditions, responding to stress and defending one's territory; locomotion (be it flying, walking, swimming, gliding, running or crawling) is one of the most important motor behaviors associated with vertebrates and invertebrates alike (Kohsaka, et al., 2017) .
In humans as well, Ataxia, Dystonia, essential tremors, Huntington's disease Parkinson's disorder, and depression; are a few out of many disorders linked with deficits in locomotor abilities (Anon., n.d.). General characteristics of the genetic makeup of complex behavioral systems (locomotion) are likely to share a common background, …show more content…

Lack of control of coordination is usually attributed to mechanosensory defects.

Why Drosophila?

Drosophila importance: Drosophila is the perfect model organism due to the numerous candidate genes it possesses, from which respective human homologs can be sourced and investigated for roles in mechano-sensory functions, diseases, and development (Jarman, 2002). Several genetic screens of mechano-transduction conducted in Drosophila is the basis for understanding molecular workings behind these processes. These are demonstrated by the behavioral screens that are performed, be it touch insensitivity or uncoordinated motor control leading to locomotor deficit movements in larvae and adults both (Jarman, 2002) .

What controls larval …show more content…

Locomotion, in general, is a polygenic trait. The enhanced locomotion demonstrated by the loss of pickpocket protein (Joshua A. Ainsley, et al., 2003), or the unc and uncl genes associated with low viability and uncoordinated movements resulting in reduced locomotor activity, (Kernan, et al., 1994) , imply the importance of few out of many genes on

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