Essay On Pharmacogenomics
Abstract
In this project, we studied about various types of traditional medicine systems but focussed mainly on Indian and Chinese medicine systems.
We studied the basics of both the systems including basic elements, their importance and also the comparisons and differences between the two systems. Also it was seen that the tastes in both systems are similar with different significance. And the relation of these traditional systems with the modern science development of pharmacogenomics. After understanding the basics of the two medicine systems, we studied about the experiments performed by the scientists to prove the interrelation between the traditional medicine systems and modern science. One of the experiment was based on screening of
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Yin-Yang imbalance is seen as the reason for development of disease states. Its theory of personalized medicine is a fundamental aspect of TCM, and medicines are prescribed in accordance with a patient's constitution. TCM recognizes that both susceptibility to disease, and drug response depend on individual constitution.[1,2]
The two experiments we studied were of titles:
a) Traditional Medicine to Modern Pharmacogenomics: Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability
b) Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula
Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map
In experiment 1, we studied the gene polymorphism associated with metabolic variability. The scientists hypothesized that drug metabolism and genetic polymorphism of drug metabolizing enzymes (DME) are related to each other. Also, that mutations in gene coding for DMEs may result in variants with high, low or no activity.[5]
The methods used in these experiments were as
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