3.3. Synthetic methodologies for dihydropyrimidinones 3.3.1. Classical method Scheme-1: The conventional method for the synthesis of DHPMs is the one-pot three-component reaction of benzaldehyde, ethyl acetoacetate and urea in the presence of an acid catalyst. The product of this novel one-pot, three components synthesis that precipitated on cooling of the reaction mixture was identified as 3,4-dihydropyrimidin-2(1H)-one and this reaction came to be known as “Biginelli reaction”, or “Biginelli condensation”, or “Biginelli dihydropyrimidine synthesis” after the name of its inventor “Pietro Biginelli”.1 Mechanism Forty years after Biginelli’s initial report, the first mechanism for the synthesis of DHPMs was conducted by Folkers and Johnson
The goal of the experiment is to synthesize a bromohexane compound from 1-hexene and HBr(aq) under reflux conditions and use the silver nitrate and sodium iodide tests to determine if the product is a primary or secondary hydrocarbon. The heterogeneous reaction mixture contains 1-hexene, 48% HBr(aq), and tetrabutylammonium bromide and was heated to under reflux conditions. Heating under reflux means that the reaction mixture is heated at its boiling point so that the reaction can proceed at a faster rate. The attached reflux condenser allows volatile substances to return to the reaction flask so that no material is lost. Since alkenes are immiscible with concentrated HBr, tetrabutylammonium bromide is used as a phase-transfer catalyst.
As mentioned in number 13, the data for the melting point makes sense because my pure product and given compound almost perfectly matched. 17. Again as explained in number 14, the TLC data made sense because my pure compound and 4-tert-butylbenzyl phenol had similar distances from the solvent origin of the plate. The presence of benzyl bromide and benzyl alcohol also explains how not all the product dissolved in the filtrate. The possible explanations and changes to make are similar to the previous questions.
One of the reactions you observed resulted in this product: NaCl + H2O + CO2 (g)? What well did this reaction occur in? Describe how the observations for this reaction support your answer. B BoldI ItalicsU Underline Bulleted list Numbered list Superscript Subscript70 Words A reaction I observed in number 1.) Sodium Bicarbonate mixed with Hydrochloric acid.
The reagents used were Diphenylamine reagent which contains concentrated H2SO4. The standard solution used for this test is the deoxyribose standard solution. In the sample, only a faint blue solution appeared, which indicates a small presence of deoxyribose. In test for Phosphate, the standard solution was the Phosphate solution and the reagents used were concentrated H2SO4, concentrated HNO3, 2.5% ammonium molybdate solution. The principle involved in this test is the precipitation of phosphate which bores a yellow-colored solution and yellow precipitate.
Introduction Grignard reagent is considered as an organometallic compound or it's the composition of electrophilic and nucleophilic that electrophilic is the carbon atom of organic halide which is directly attached to the halogen, it's reactivity can be switched to the nucleophilic reactivity by conversion an organomagnesium halide. It has the general formula of (RMgX) and it has a general nomenclature which it's called magnesium alkyl halide. We can get Grignard reagent by adding one of solutions of alkyl halide to an ether, slowly. Then, garbling them that's leads to the boiling of solution and magnesium becomes disappeared so, we can get the reagent. Grignard reagent is also considered as the best known reagent of all organometallic compounds, as carbon atom is connected to a metal atom which may be
Lab Report 10: Nitration of Bromobenzene Raekwon Filmore CM 244 Section 40 March 27, 2018 Introduction: For this experiment, nitration of bromobenzene was the focus of the lab. The benzene is an aromatic compound and when it reacts with wither a mixture of sulfuric acid or nitric acid creates what is known as a nitro group. The formation of the nitro group is possible because it is an electrophilic aromatic substitution reaction. The creation of the nitronium ion is shown below: The reaction with the nitronium ion with bromobenzene creates three products instead of one. Depending on where the nitronium group or the alpha complexes of the reaction is on the ring, determines whether the product will be meta, para or ortho.
The IUPAC nomenclature for haloperidol is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one. Figure 1: 2-D structure of haloperidol (taken from https://pubchem.ncbi.nlm.nih.gov/compound/3559) Tacke et al (2008) analysed haloperidol in order to determine the physicochemical properties of the drug. At a pH of 7.4, it was discovered that haloperidol has a distribution coefficient (Log D) of
Dehydration of 2-Methylcyclohexanol Sura Abedali Wednesday 2:00 PM January 31, 2018 Introduction: Dehydration reactions are important processes to convert alcohols into alkenes. It is a type of elimination reaction that removes an “-OH” group from one carbon molecule and a hydrogen from a neighboring carbon, thus releasing them as a water molecule (H2O) and forming a pi bond between the two carbons1. In this experiment, 2-methylcyclohexanol undergoes dehydration to form three possible products: methylenecylcohexane, 1-methylcyclohexene, and 3-methylcyclohexene in a Hickman still apparatus. Adding 85% Phosphoric Acid to protonates the “-OH” group, turning it into a better leaving group and initiating the dehydration reaction. The dehydration of 2-methylcyclohexanol takes place at the bottom of the Hickman still.
N O O H2SO4 rt, 5 min. + N N N O O O Cl Cl Cl N O O H H Cl 32 34 35 32 33 10 Mono-halogenation (-Cl, -I, -Br) of isatin (32) can be achieved by reacting Nhalosaccharins 36 with isatin in the presence of SiO2 at r.t to specifically produce the 5-halo derivatives 37 as reported by de Silva and de Mattos.20 This method is an alternative to the use of highly toxic and corrosive Cl2 and Br2, which can lead to other products such as 5,7-dibromo- 3,3-dialkoxyoxindole when the bromination of isatin is attempted in alcoholic media.22 N O O SiO2 CH2Cl2 , rt. + N O O H H X S N O O O X X = Cl, Br, I N-Alkylation of Isatin Various methods have been used for the preparation of N-alkylated isatins which can be successfully achieved under basic conditions using alkyl chlorides, bromides, and iodides; as well as reactive allyl-, benzyl-, and propargyl halides. Conventional heating is often employed to produce the N-alkylated isatins from temperatures of from 40-100ºC under reflux. In general, the N-alkylation of isatin proceeds by reacting the isatin (32) substrate with any variety of base and solvent combination shown in Table 1, to