Urticaria Case Study

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DETERMINING THE MINIMAL CLINICALLY IMPORTANT DIFFERENCE OF THE URTICARIA ACTIVITY SCORE AND INVESTIGATING THE VALIDITY, RELIABILITY AND RESPONSIVENESS TO CHANGE IN THE TAMIL POPULATION
INTRODUCTION:
Chronic urticaria is a skin disorder characterized by daily or episodic wheals or angioedema that is present for more than 6 weeks and recur frequently over months or years[2]. It may be spontaneous, inducible or both. Chronic urticaria affects approximately 1.8% of the adult population and 0.1-0.3% of the children population with a period prevalence past 12 months of 0.6-0.8%[1]. It results from mast cell degranulation, which causes extravasation of the plasma into the dermis, thus forming characteristic hives. No major external cause or underlying
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Urticaria is assessed with the Urticaria Activity Score (UAS). It measures two symptoms on a daily basis on a scale of 0-3-number of wheals (0:no wheals to 3:>50 wheals) and intensity of itching (0:no itching to 3:severe itching). These scores are added together on each of the days for seven days to give an aggregate ranging from 0-42.
Minimal clinically important differences (MCID) are patient derived scores that reflect changes in a clinical intervention that are meaningful for the patient. It is used to directly involve and improve the participation of patients in the judgement of the benefit of the health care received. The Dermatology Life Quality Index (DLQI) will be used to determine the value of MCID.
OBJECTIVES:
To determine the Minimal Clinically Important Difference of the UAS7 in the Tamil population.
To investigate the validity, reliability and responsiveness to change of the UAS7 among the Tamil population.
METHODOLOGY:
The study will be conducted for a period of two months in the Skin OPD, Department of Dermatology,
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Determining the minimal clinically important difference and responsiveness of the Dermatology Life Quality Index (DLQI): further data. Dermatology. 2015;230(1):27-33
5 – Finlay AY and Lhan GK. Dermatology Life Quality Index (DLQI): a simple practical measure for routine clinical use. Clin Exp Dermatol 1994; 19:210-216
6 – Basra MK, Fenech R, Gatt RM, Salek MS and Finlay AY. The Dermatology Life Quality Index 1994-2007: a comprehensive review of validation data and clinical results. Br J Dermatol 2008; 159:997-1035.
7 – Hongbo Y, Thomas CL, Harrison MA, Salek MS and Finlay AY. Translating the science of quality of life into practice: What do dermatology life quality index scores mean? J Invest Dermatol 2005; 125:659-64
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9 – Hays RD, Hadorn D. Responsiveness to change: an aspect of validity, not a separate dimension. Qual Life Res. 1992

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